CetuGEX and cetuximab in recurrent/metastatic squamous cell carcinoma of the head and neck (RM-HNSCC): PK/PD results from the phase II RESGEX study.
H Baumeister, A Zurlo, J Fayette, B Dietrich, U Keilholz - 2018 - ascopubs.org
61 Background: Standard treatment for RM-HNSCC is a combination of cisplatin (P), 5-FU
(F), and the EGFR blocking monoclonal antibody (mAb) cetuximab (C). The mAb CetuGEX …
(F), and the EGFR blocking monoclonal antibody (mAb) cetuximab (C). The mAb CetuGEX …
Efficacy and safety of CetuGEX in recurrent/metastatic squamous cell carcinoma of the head and neck (RM-HNSCC): Results from the randomized phase II RESGEX …
U Keilholz, A Kawecki, A Dietz, B Zurawski… - 2018 - ascopubs.org
59 Background: Standard treatment for RM-HNSCC is a combination of cisplatin (P), 5-FU
(F), and the epidermal growth factor receptor (EGFR) blocking monoclonal antibody …
(F), and the epidermal growth factor receptor (EGFR) blocking monoclonal antibody …
Cetuximab in recurrent/metastatic (R&M) squamous cell carcinoma of the head and neck (SCCHN) refractory to first-line platinum-based therapies
JB Vermorken, J Bourhis, J Trigo, M Kies… - Journal of Clinical …, 2005 - ascopubs.org
5505 Background: Patients with R&M SCCHN have a poor prognosis. Patients failing first-
line therapy have few therapeutic options. Cetuximab (Erbitux) is an IgG1 monoclonal …
line therapy have few therapeutic options. Cetuximab (Erbitux) is an IgG1 monoclonal …
Phase I study of cetuximab in combination with cisplatin or carboplatin and 5-fluorouracil (5-FU) in patients (pts) with recurrent and/or metastatic squamous cell …
Y Humblet, E Vega-Villegas, R Mesia… - Journal of Clinical …, 2004 - ascopubs.org
5513 Background: The goal of this study was to investigate the safety and efficacy of
cetuximab (Erbitux), an IgG1 monoclonal antibody targeting the EGFR, given in combination …
cetuximab (Erbitux), an IgG1 monoclonal antibody targeting the EGFR, given in combination …
Cetuximab, docetaxel, and cisplatin (TPEx) as first-line treatment in patients with recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN …
J Guigay, J Fayette, A Dillies, C Sire… - Journal of Clinical …, 2011 - ascopubs.org
5567 Background: Cetuximab in combination with platinum and 5FU has become a
standard in first-line treatment of patients (pts) with R/M SCCHN. Cetuximab and taxane …
standard in first-line treatment of patients (pts) with R/M SCCHN. Cetuximab and taxane …
Cetuximab, docetaxel, and cisplatin (TPEx) as first-line treatment in patients with recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN …
J Guigay, J Fayette, AF Dillies, C Sire, JN Kerger… - 2012 - ascopubs.org
5505 Background: Cetuximab in combination with platinum and 5FU (PFEx) has become a
standard in first-line treatment of patients (pts) with R/M SCCHN. Cetuximab and taxane …
standard in first-line treatment of patients (pts) with R/M SCCHN. Cetuximab and taxane …
Cetuximab monotherapy is active in patients (pts) with platinum-refractory recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN): results of a …
J Trigo, R Hitt, P Koralewski, E Diaz-Rubio… - Journal of Clinical …, 2004 - ascopubs.org
5502 Background: Pts with refractory SCCHN have a poor prognosis with few therapeutic
options. Cetuximab (Erbitux), an IgG1 monoclonal antibody that binds selectively to EGFR …
options. Cetuximab (Erbitux), an IgG1 monoclonal antibody that binds selectively to EGFR …
Drug Insight: cetuximab in the treatment of recurrent and metastatic squamous cell carcinoma of the head and neck
J Bernier - Nature Clinical Practice Oncology, 2008 - nature.com
Patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck
(SCCHN) have a poor prognosis, particularly those whose disease has progressed on …
(SCCHN) have a poor prognosis, particularly those whose disease has progressed on …
The contribution of cetuximab in the treatment of recurrent and/or metastatic head and neck cancer
MA Tejani, RB Cohen, R Mehra - Biologics: Targets and Therapy, 2010 - Taylor & Francis
Recurrent and/or metastatic squamous cell carcinoma of the head and neck (HNSCC)
continues to be a source of significant morbidity and mortality worldwide. Agents that target …
continues to be a source of significant morbidity and mortality worldwide. Agents that target …
Overview of the efficacy of cetuximab in recurrent and/or metastatic squamous cell carcinoma of the head and neck in patients who previously failed platinum‐based …
BACKGROUND. The epidermal growth factor receptor (EGFR) inhibitor cetuximab is active
in recurrent and/or metastatic squamous cell carcinoma of the head and neck (SCCHN). The …
in recurrent and/or metastatic squamous cell carcinoma of the head and neck (SCCHN). The …
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