Chemistry, antiproliferative properties, tumor selectivity, and molecular mechanisms of novel gold (III) compounds for cancer treatment: a systematic study

A Casini, G Kelter, C Gabbiani, MA Cinellu… - JBIC Journal of …, 2009 - Springer
The antiproliferative properties of a group of 13 structurally diverse gold (III) compounds,
including six mononuclear gold (III) complexes, five dinuclear oxo-bridged gold (III) …

Chemical biology of anticancer gold (III) and gold (I) complexes

T Zou, CT Lum, CN Lok, JJ Zhang… - Chemical Society Reviews, 2015 - pubs.rsc.org
Gold complexes have recently gained increasing attention in the design of new metal-based
anticancer therapeutics. Gold (III) complexes are generally reactive/unstable under …

Gold (III) complexes with 2-substituted pyridines as experimental anticancer agents: Solution behavior, reactions with model proteins, antiproliferative properties

L Maiore, MA Cinellu, S Nobili, I Landini, E Mini… - Journal of Inorganic …, 2012 - Elsevier
Gold (III) compounds form a family of promising cytotoxic and potentially anticancer agents
that are currently undergoing intense preclinical investigations. Four recently synthesized …

Gold compounds as anticancer agents: chemistry, cellular pharmacology, and preclinical studies

S Nobili, E Mini, I Landini, C Gabbiani… - Medicinal research …, 2010 - Wiley Online Library
Gold compounds are a class of metallodrugs with great potential for cancer treatment.
During the last two decades, a large variety of gold (I) and gold (III) compounds are reported …

Gold (III) complexes as potential antitumor agents: solution chemistry and cytotoxic properties of some selected gold (III) compounds

L Messori, F Abbate, G Marcon, P Orioli… - Journal of medicinal …, 2000 - ACS Publications
Gold (III) complexes generally exhibit interesting cytotoxic and antitumor properties, but until
now, their development has been heavily hampered by their poor stability under …

Synthesis, structural characterization, solution behavior, and in vitro antiproliferative properties of a series of gold complexes with 2-(2′-pyridyl) benzimidazole as …

M Serratrice, MA Cinellu, L Maiore, M Pilo… - Inorganic …, 2012 - ACS Publications
A variety of gold (III) and gold (I) derivatives of 2-(2′-pyridyl) benzimidazole (pbiH) were
synthesized and fully characterized and their antiproliferative properties evaluated in a …

Gold-based medicine: a paradigm shift in anti-cancer therapy?

CI Yeo, KK Ooi, ERT Tiekink - Molecules, 2018 - mdpi.com
A new era of metal-based drugs started in the 1960s, heralded by the discovery of potent
platinum-based complexes, commencing with cisplatin [(H3N) 2PtCl2], which are effective …

Proteomics as a tool to disclose the cellular and molecular mechanisms of selected anticancer gold compounds

T Gamberi, A Pratesi, L Messori, L Massai - Coordination Chemistry …, 2021 - Elsevier
Gold compounds form an attractive class of cytotoxic metal compounds of potential
application as anticancer agents. Notably, the mode of action of cytotoxic gold compounds …

Therapeutic applications of gold complexes: lipophilic gold (III) cations and gold (I) complexes for anti-cancer treatment

CM Che, RWY Sun - Chemical Communications, 2011 - pubs.rsc.org
Gold and its complexes have long been known to display unique biological and medicinal
properties. Extensive cell-based (in vitro) and animal (in vivo) studies have revealed the …

[PDF][PDF] Gold (III) compounds as new family of anticancer drugs

L Messori, G Marcon, P Orioli - Bioinorganic chemistry and …, 2003 - Wiley Online Library
Gold (III) complexes are emerging asa new class of metal complexes with outstanding
cytotoxic properties and are presently being evaluated as potential antitumor agents. This …