Chemistry, antiproliferative properties, tumor selectivity, and molecular mechanisms of novel gold (III) compounds for cancer treatment: a systematic study
The antiproliferative properties of a group of 13 structurally diverse gold (III) compounds,
including six mononuclear gold (III) complexes, five dinuclear oxo-bridged gold (III) …
including six mononuclear gold (III) complexes, five dinuclear oxo-bridged gold (III) …
Chemical biology of anticancer gold (III) and gold (I) complexes
T Zou, CT Lum, CN Lok, JJ Zhang… - Chemical Society Reviews, 2015 - pubs.rsc.org
Gold complexes have recently gained increasing attention in the design of new metal-based
anticancer therapeutics. Gold (III) complexes are generally reactive/unstable under …
anticancer therapeutics. Gold (III) complexes are generally reactive/unstable under …
Gold (III) complexes with 2-substituted pyridines as experimental anticancer agents: Solution behavior, reactions with model proteins, antiproliferative properties
Gold (III) compounds form a family of promising cytotoxic and potentially anticancer agents
that are currently undergoing intense preclinical investigations. Four recently synthesized …
that are currently undergoing intense preclinical investigations. Four recently synthesized …
Gold compounds as anticancer agents: chemistry, cellular pharmacology, and preclinical studies
Gold compounds are a class of metallodrugs with great potential for cancer treatment.
During the last two decades, a large variety of gold (I) and gold (III) compounds are reported …
During the last two decades, a large variety of gold (I) and gold (III) compounds are reported …
Gold (III) complexes as potential antitumor agents: solution chemistry and cytotoxic properties of some selected gold (III) compounds
Gold (III) complexes generally exhibit interesting cytotoxic and antitumor properties, but until
now, their development has been heavily hampered by their poor stability under …
now, their development has been heavily hampered by their poor stability under …
Synthesis, structural characterization, solution behavior, and in vitro antiproliferative properties of a series of gold complexes with 2-(2′-pyridyl) benzimidazole as …
A variety of gold (III) and gold (I) derivatives of 2-(2′-pyridyl) benzimidazole (pbiH) were
synthesized and fully characterized and their antiproliferative properties evaluated in a …
synthesized and fully characterized and their antiproliferative properties evaluated in a …
Gold-based medicine: a paradigm shift in anti-cancer therapy?
CI Yeo, KK Ooi, ERT Tiekink - Molecules, 2018 - mdpi.com
A new era of metal-based drugs started in the 1960s, heralded by the discovery of potent
platinum-based complexes, commencing with cisplatin [(H3N) 2PtCl2], which are effective …
platinum-based complexes, commencing with cisplatin [(H3N) 2PtCl2], which are effective …
Proteomics as a tool to disclose the cellular and molecular mechanisms of selected anticancer gold compounds
Gold compounds form an attractive class of cytotoxic metal compounds of potential
application as anticancer agents. Notably, the mode of action of cytotoxic gold compounds …
application as anticancer agents. Notably, the mode of action of cytotoxic gold compounds …
Therapeutic applications of gold complexes: lipophilic gold (III) cations and gold (I) complexes for anti-cancer treatment
CM Che, RWY Sun - Chemical Communications, 2011 - pubs.rsc.org
Gold and its complexes have long been known to display unique biological and medicinal
properties. Extensive cell-based (in vitro) and animal (in vivo) studies have revealed the …
properties. Extensive cell-based (in vitro) and animal (in vivo) studies have revealed the …
[PDF][PDF] Gold (III) compounds as new family of anticancer drugs
Gold (III) complexes are emerging asa new class of metal complexes with outstanding
cytotoxic properties and are presently being evaluated as potential antitumor agents. This …
cytotoxic properties and are presently being evaluated as potential antitumor agents. This …
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