Copy Number Variations (CNVs) and Single Nucleotide Polymorphisms (SNPs) have been
the major focus of most large-scale comparative genomics studies to date. Here, we discuss …

Genotype-to-phenotype mapping commonly focuses on two major classes of mutations:
single nucleotide polymorphisms (SNPs) and copy number variation (CNV). Here, we …

Tandem repeats are intrinsically highly variable sequences since repeat units are often lost
or gained during replication or following unequal recombination events. Because of their low …

Repetitive DNA sequences constitute a large fraction of the genomes of humans and other
animal species. Tandem repeats are a major class of repetitive DNA and the extent of their …

Amino acid tandem repeats are found in a large number of eukaryotic proteins. They are
often encoded by trinucleotide repeats and exhibit high intra-and interspecies size variability …

Because natural selection is commonly presumed to minimize mutation rates, the discovery
of mutationally unstable simple sequence repeats (SSRs) in many functional genomic …

Accumulating evidence suggests that many classes of DNA repeats exhibit attributes that
distinguish them from other genetic variants, including the fact that they are more liable to …

Expansions of simple tandem repeats are responsible for almost 50 human diseases, the
majority of which are severe, degenerative, and not currently treatable or preventable. In this …

Tandem repeats are common in eukaryotic genomes, but due to difficulties in assaying them
remain poorly studied. Here, we demonstrate the utility of Nanostring technology as a …

Tandem repeats are common features of both prokaryote and eukaryote genomes, where
they can be found not only in intergenic regions but also in both the noncoding and coding …