Mycobacterium tuberculosis PPE51 inhibits autophagy by suppressing toll-like receptor 2-dependent signaling

EJ Strong, J Wang, TW Ng, SA Porcelli, S Lee - MBio, 2022 - Am Soc Microbiol
Autophagy is an ubiquitous homeostatic pathway in mammalian cells and plays a significant
role in host immunity. Substantial evidence indicates that the ability of Mycobacterium …

Identification of autophagy-inhibiting factors of Mycobacterium tuberculosis by high-throughput loss-of-function screening

EJ Strong, KL Jurcic Smith, NK Saini, TW Ng… - Infection and …, 2020 - Am Soc Microbiol
The interaction of host cells with mycobacteria is complex and can lead to multiple outcomes
ranging from bacterial clearance to progressive or latent infection. Autophagy is recognized …

Mycobacterium tuberculosis Rv0790c inhibits the cellular autophagy at its early stage and facilitates mycobacterial survival

J Fang, C Dong, S Xiong - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
Rv0790c is predicted to be a conserved hypothetical protein encoded by Mycobacterium
tubercul osis (Mtb). However, its function in Mtb infection remains largely unknown. In this …

ESAT6 inhibits autophagy flux and promotes BCG proliferation through MTOR

H Dong, W Jing, Z Runpeng, X Xuewei, M Min… - Biochemical and …, 2016 - Elsevier
In recent years, increasing studies have found that pathogenic Mycobacterium tuberculosis
(Mtb) inhibits autophagy, which mediates the anti-mycobacterial response, but the …

Mycobacterium tuberculosis PE_PGRS20 and PE_PGRS47 proteins inhibit autophagy by interaction with rab1A

EJ Strong, TW Ng, SA Porcelli, S Lee - MSphere, 2021 - Am Soc Microbiol
Autophagy is a fundamental cellular process that has important roles in innate and adaptive
immunity against a broad range of microbes. Many pathogenic microbes have evolved …

Shedding light on autophagy during human tuberculosis. A long way to go

JM Pellegrini, NL Tateosian, MP Morelli… - Frontiers in Cellular …, 2022 - frontiersin.org
Immunity against Mycobacterium tuberculosis (Mtb) is highly complex, and the outcome of
the infection depends on the role of several immune mediators with particular temporal …

Regulatory mechanisms of autophagy-targeted antimicrobial therapeutics against mycobacterial infection

P Silwal, S Paik, JK Kim, T Yoshimori… - Frontiers in Cellular and …, 2021 - frontiersin.org
Mycobacterium tuberculosis (Mtb) is an intracellular pathogen causing human tuberculosis,
an infectious disease that still remains as a global health problem. Autophagy, a lysosomal …

Autophagy: A new strategy for host-directed therapy of tuberculosis

S Paik, JK Kim, C Chung, EK Jo - Virulence, 2019 - Taylor & Francis
Tuberculosis (TB), which is primarily caused by the major etiologic agent Mycobacterium
tuberculosis (Mtb), remains a serious infectious disease worldwide. Recently, much effort …

Mycobacteria and autophagy: many questions and few answers

M Liang, Z Habib, K Sakamoto, X Chen… - Current issues in …, 2017 - mdpi.com
Tuberculosis (TB) is an ancient disease caused by Mycobacterium tuberculosis (Mtb). TB is
one of the world's deadliest diseases, with one-third of infected individuals falling ill each …

Autophagy-activating strategies to promote innate defense against mycobacteria

YS Kim, P Silwal, SY Kim, T Yoshimori… - Experimental & Molecular …, 2019 - nature.com
Mycobacterium tuberculosis (Mtb) is a major causal pathogen of human tuberculosis (TB),
which is a serious health burden worldwide. The demand for the development of an …