Mycobacterium tuberculosis PPE51 inhibits autophagy by suppressing toll-like receptor 2-dependent signaling
EJ Strong, J Wang, TW Ng, SA Porcelli, S Lee - MBio, 2022 - Am Soc Microbiol
Autophagy is an ubiquitous homeostatic pathway in mammalian cells and plays a significant
role in host immunity. Substantial evidence indicates that the ability of Mycobacterium …
role in host immunity. Substantial evidence indicates that the ability of Mycobacterium …
Identification of autophagy-inhibiting factors of Mycobacterium tuberculosis by high-throughput loss-of-function screening
The interaction of host cells with mycobacteria is complex and can lead to multiple outcomes
ranging from bacterial clearance to progressive or latent infection. Autophagy is recognized …
ranging from bacterial clearance to progressive or latent infection. Autophagy is recognized …
Mycobacterium tuberculosis Rv0790c inhibits the cellular autophagy at its early stage and facilitates mycobacterial survival
J Fang, C Dong, S Xiong - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
Rv0790c is predicted to be a conserved hypothetical protein encoded by Mycobacterium
tubercul osis (Mtb). However, its function in Mtb infection remains largely unknown. In this …
tubercul osis (Mtb). However, its function in Mtb infection remains largely unknown. In this …
ESAT6 inhibits autophagy flux and promotes BCG proliferation through MTOR
H Dong, W Jing, Z Runpeng, X Xuewei, M Min… - Biochemical and …, 2016 - Elsevier
In recent years, increasing studies have found that pathogenic Mycobacterium tuberculosis
(Mtb) inhibits autophagy, which mediates the anti-mycobacterial response, but the …
(Mtb) inhibits autophagy, which mediates the anti-mycobacterial response, but the …
Mycobacterium tuberculosis PE_PGRS20 and PE_PGRS47 proteins inhibit autophagy by interaction with rab1A
EJ Strong, TW Ng, SA Porcelli, S Lee - MSphere, 2021 - Am Soc Microbiol
Autophagy is a fundamental cellular process that has important roles in innate and adaptive
immunity against a broad range of microbes. Many pathogenic microbes have evolved …
immunity against a broad range of microbes. Many pathogenic microbes have evolved …
Shedding light on autophagy during human tuberculosis. A long way to go
JM Pellegrini, NL Tateosian, MP Morelli… - Frontiers in Cellular …, 2022 - frontiersin.org
Immunity against Mycobacterium tuberculosis (Mtb) is highly complex, and the outcome of
the infection depends on the role of several immune mediators with particular temporal …
the infection depends on the role of several immune mediators with particular temporal …
Regulatory mechanisms of autophagy-targeted antimicrobial therapeutics against mycobacterial infection
Mycobacterium tuberculosis (Mtb) is an intracellular pathogen causing human tuberculosis,
an infectious disease that still remains as a global health problem. Autophagy, a lysosomal …
an infectious disease that still remains as a global health problem. Autophagy, a lysosomal …
Autophagy: A new strategy for host-directed therapy of tuberculosis
Tuberculosis (TB), which is primarily caused by the major etiologic agent Mycobacterium
tuberculosis (Mtb), remains a serious infectious disease worldwide. Recently, much effort …
tuberculosis (Mtb), remains a serious infectious disease worldwide. Recently, much effort …
Mycobacteria and autophagy: many questions and few answers
M Liang, Z Habib, K Sakamoto, X Chen… - Current issues in …, 2017 - mdpi.com
Tuberculosis (TB) is an ancient disease caused by Mycobacterium tuberculosis (Mtb). TB is
one of the world's deadliest diseases, with one-third of infected individuals falling ill each …
one of the world's deadliest diseases, with one-third of infected individuals falling ill each …
Autophagy-activating strategies to promote innate defense against mycobacteria
Mycobacterium tuberculosis (Mtb) is a major causal pathogen of human tuberculosis (TB),
which is a serious health burden worldwide. The demand for the development of an …
which is a serious health burden worldwide. The demand for the development of an …