Metastatic colorectal cancer in the era of personalized medicine: a more tailored approach to systemic therapy

IS Yu, WY Cheung - Canadian Journal of Gastroenterology and …, 2018 - Wiley Online Library
Colorectal cancer is the second most common malignancy diagnosed in Canada. Despite
declining incidence and mortality rates in recent years, there is still a significant number of …

Tackling refractory metastatic colorectal cancer: future perspectives

N Personeni, V Smiroldo, EF Giunta, MG Prete… - Cancers, 2021 - mdpi.com
Simple Summary Metastatic colorectal cancer (mCRC) accounts for relevant cancer-related
morbidity and mortality. Novel investigations have reshaped the molecular makeup of …

Colorectal cancer: how emerging molecular understanding affects treatment decisions.

M Sridharan, A GROTHEY… - Oncology (08909091 …, 2014 - search.ebscohost.com
The medical treatment of metastatic colorectal cancer (mCRC) has advanced significantly
over the last 10 years as the result of the introduction of several active cytotoxic and biologic …

A decade of advances in cytotoxic chemotherapy for metastatic colorectal cancer

AS Lucas, BH O'Neil, RM Goldberg - Clinical colorectal cancer, 2011 - Elsevier
Over the past decade treatment for metastatic colorectal cancer (mCRC) has advanced
beyond single-agent fluoropyrimidine use to include various cytotoxic combination regimens …

First-and second-line therapy of metastatic colorectal cancer

S Terstriep, A Grothey - Expert review of anticancer therapy, 2006 - Taylor & Francis
In the USA, colorectal cancer is the fourth most prevalent cancer and is the second leading
cause of cancer death after lung cancer. In 2006, 148,610 colorectal cancer cases are …

Optimal management of metastatic colorectal cancer: current status

AJ McRee, RM Goldberg - Drugs, 2011 - Springer
Colorectal cancer remains one of the most common causes of cancer death in the US, with
approximately a quarter of patients presenting with metastatic disease at the time of …

[HTML][HTML] Combining chemotherapy and targeted therapies in metastatic colorectal cancer

J Rodriguez, R Zarate, E Bandres… - World journal of …, 2007 - ncbi.nlm.nih.gov
Colorectal cancer remains one of the major causes of cancer death worldwide. During the
past years, the development of new effective treatment options has led to a considerable …

Targeting metastatic colorectal cancer–present and emerging treatment options

KK Ciombor, J Berlin - Pharmacogenomics and Personalized …, 2014 - Taylor & Francis
Metastatic colorectal cancer is a significant cause of morbidity and mortality in the US and
around the world. While several novel cytotoxic and biologic therapies have been …

The changing face of treatment for metastatic colorectal cancer

P Pfeiffer, CH Köhne, C Qvortrup - Expert Review of Anticancer …, 2019 - Taylor & Francis
Introduction: Since late 1990's therapy of metastatic colorectal cancer (mCRC) patients has
changed considerable, and the combination of doublet or triplet chemotherapy and a …

Systemic and targeted therapy for advanced colon cancer

SR Hegde, W Sun, JP Lynch - Expert review of gastroenterology & …, 2008 - Taylor & Francis
Colorectal cancer (CRC) is the third most common malignancy and the second most
common cause of cancer-related death in the USA. Prognosis is best when the disease is …