Type 2 diabetes (T2D) is caused by relative insulin deficiency, due in part to reduced β-cell
mass (,). Therapies aimed at expanding β-cell mass may be useful to treat T2D. Although …

The onset of type 2 diabetes is characterized by transition from successful to failed insulin
secretory compensation to obesity-related insulin resistance and dysmetabolism. Energy …

Both short-(1 wk) and long-term (2–12 mo) high-fat diet (HFD) studies reveal enhanced β-
cell mass due to increased β-cell proliferation. β-Cell proliferation following HFD has been …

Aims/hypothesis Increased dietary fat intake is associated with obesity and insulin
resistance, but studies have shown that the subsequent increase in insulin release is not …

Because obesity rates have increased dramatically over the past 3 decades, type 2 diabetes
has become increasingly prevalent as well. Type 2 diabetes is associated with decreased …

A major goal in diabetes research is to find ways to enhance the mass and function of insulin
secreting β-cells in the endocrine pancreas to prevent and/or delay the onset or even …

In healthy adult mice, the β cell population is not maintained by stem cells but instead by the
replication of differentiated β cells. It is not known, however, whether all β cells contribute …

Pancreatic β-cells normally produce adequate insulin to control glucose homeostasis, but in
obesity-related diabetes, there is a presumed deficit in insulin production and secretory …

The physiological mechanisms underlying the compensatory growth of β-cell mass in insulin-
resistant states are poorly understood. Using the insulin-resistant Zucker fatty (fa/fa)(ZF) rat …

The failure to expand functional pancreatic β-cell mass in response to increased metabolic
demand is a hallmark of type 2 diabetes. Lineage tracing studies indicate that replication of …