Regeneration of mature cells that produce functional insulin represents a major focus and a
challenge of current diabetes research aimed at restoring beta cell mass in patients with …

Although stem cell populations mediate regeneration of rapid turnover tissues, such as skin,
blood, and gut, a stem cell reservoir has not been identified for some slower turnover …

Cure of type 1 diabetes (T1D) by immune intervention at disease onset depends on the
restoration of insulin secretion by endogenous β-cells. However, little is known about the …

Aim To characterise changes in pancreatic beta cell mass during the development of
diabetes in untreated male C57BLKS/J db/db mice. Methods Blood samples were collected …

Aim Poorly controlled diabetes is characterised by a partial or complete loss of pancreatic
islet β-cells, which deprives the remaining islet cells of important β-cell-derived soluble …

Diabetes is characterized by high blood glucose level due to either autoimmune destruction
of islet β-cells or insufficient insulin secretion or glucose non-responsive production of …

Efforts to restore β-cell number or mass in type 1 diabetes (T1D) must combine an
intervention to stimulate proliferation of remaining β-cells and an intervention to mitigate or …

Stem cell-derived β (SC-β) cells could provide unlimited human β cells toward a curative
diabetes treatment. Differentiation of SC-β cells yields transplantable islets that secrete …

Glucose homeostasis greatly depends on the match between fluctuating insulin demands
and adjusted rates of insulin secretion, which is the function of pancreatic beta cells …

Impaired β-cell function and insufficient β-cell mass compensation are twin pathogenic
features that underlie type 2 diabetes (T2D). Current therapeutic strategies continue to …