Maintaining placental syncytiotrophoblast, a specialized multinucleated transport epithelium,
is essential for normal human pregnancy. Syncytiotrophoblast continuously renews through …

Transfer experiments by Stulc et al.(1969) gave evidence for the existence of water-filled
routes, so-called pores or channels, across the rabbit placenta. Their radius was calculated …

Synexin (annexin V11) is a cytosolic calcium binding protein, which was originally isolated
from bovine adrenal medulla as part of a search for proteins involved in membrane fusion …

Aldosterone modulates the activity of the epithelial sodium channel (ENaC) through
changes in its trafficking, membrane expression and open probability. Plasma levels of …

FIGURE 1 Channel activity of recombinant human synexin. Channel forming activity was
incorporated into a PS bilayer formed at the tip of a patch pipet by an increase in ambient …

The functional hallmark of annexins is the ability to bind to the surface of phospholipid
membranes in a reversible, Ca2+-dependent manner. We now report that human annexin V …

Trophoblasts, a cell type found in the placenta, play a pivotal role in the function of the
placenta as a barrier between the maternal fluid and the fetus. Recently, claudin, a 24-kDa …

The conformational preferences of AnxIN26, a peptide corresponding to residues 2–26 of
human annexin I, were investigated using CD and NMR spectroscopy. CD results showed …

The sorting of apical and basolateral proteins into vesicular carriers takes place in the trans-
Golgi network (TGN) in MDCK cells. We have previously analyzed the protein composition of …

The structure of recombinant human annexin III was solved to 1.8 Å resolution. Though
homologous to annexin I and V, the annexin III structure shows significant differences. The …