Age is the main risk factor for the onset of neurodegenerative diseases. A decline of
mitochondrial function has been observed in several age-dependent neurodegenerative …

Mitochondria play key roles in ATP supply, calcium homeostasis, redox balance control and
apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic …

Calcium signaling is essential for neuronal function, and its dysregulation has been
implicated across neurodegenerative diseases, including Alzheimer's disease (AD). A close …

Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …

Mitochondria play a critical role in neuron viability or death as it regulates energy
metabolism and cell death pathways. They are essential for cellular energy metabolism …

Mitochondria are essential for ensuring numerous fundamental physiological processes
such as cellular energy, redox balance, modulation of Ca2+ signaling and important …

Alzheimer's disease (AD) is the most frequent cause of age-related neurodegeneration and
cognitive impairment, and there are currently no broadly effective therapies. The underlying …

Significance: Alzheimer's disease (AD) is an age-related progressive neurodegenerative
disorder mainly affecting elderly individuals. The pathology of AD is characterized by …

Mitochondrial dysfunction has been implicated in the pathogenesis of almost all
neurological diseases, including Alzheimer's disease (AD). Historically, a primary focus in …

Functional mitochondria are vital to accomplish their key role in the cell, by maintaining the
energy metabolism, buffering of the Ca 2+ signal and directing the cell death mechanism …