Saturated and mono-unsaturated fatty acids exert differential effects on pancreatic β-cell
viability during chronic exposure. Long chain saturated molecules (eg palmitate) are …

Background and purpose: Exposure of pancreatic β‐cells to long‐chain free fatty acids leads
to differential responses according to the chain length and degree of unsaturation. In …

Palmitate negatively affects insulin secretion and apoptosis in the pancreatic β‐cell. The
detrimental effects are abolished by elongating and desaturating the fatty acid into oleate. To …

Aims: In this study we have tested the effect of unsaturated fatty acids on the proapoptotic
effects of saturated fatty acids in the human pancreatic β-cells NES2Y. Results: We found …

Long-chain saturated fatty acids are cytotoxic to pancreatic β-cells while shorter-chain
saturated and long-chain unsaturated molecules are better tolerated. Mono-unsaturated fatty …

Lipid accumulation in pancreatic β-cells is thought to cause its dysfunction and/or
destruction via apoptosis. Our studies show that incubation of the β-cell line RINm5F with the …

Chronic exposure of pancreatic β-cells to long-chain fatty acids can cause loss of secretory
function and enhanced apoptosis by a process of 'lipotoxicity', which may be a contributory …

Palmitic acid (PAM), one of the most common saturated fatty acid (SFA) in animals and
plants, has been shown to induce apoptosis in exocrine pancreatic AR42J cells. In this …

Chronic surplus of dietary consumption, typical to obesity, results in overflow of fat to non-
adipose tissues. Intracellular accumulation of fat in non-adipose tissues is associated with …

Chronic exposure of pancreatic β-cells to saturated non-esterified fatty acids can lead to
inhibition of insulin secretion and apoptosis. Several previous studies have demonstrated …