ABSTRACT BACKGROUND AND OBJECTIVES: Ideal models should reproduce just
sensory deficits, such as alodynia, hyperalgesia and spontaneous pain for short periods …

Neuropathic Pain (NP) is a painful condition which is a direct consequence of a lesion or
disease affecting the somatosensory system with symptoms like allodynia, hyperalgesia. It …

Neuropathic pain can be triggered by various traumatic insults, including direct peripheral
nerve and spinal cord injury; viral infections, including herpes zoster and HIV; metabolic …

Animal models of pain consist of modeling a pain-like state and measuring the consequent
behavior. The first animal models of neuropathic pain (NP) were developed in rodents with a …

Animal models are pivotal for understanding the mechanism of neuropathic pain and
development of effective therapy for its optimal management. A battery of neuropathic pain …

Chronic pain can originate from injury or dysfunction in the peripheral nervous system, and
currently available therapeutic methods are often ineffective. Despite the clinical …

Introduction Animal disease models are predictive for signs seen in disease. They may
rarely mimic all signs in a specific disease in humans with respect to etiology, cause or …

Different laboratory animal models of neuropathic pain that replicate pathophysiological
changes in patients have been developed. In most animal models of neuropathic pain, both …

This review deals with physiological and biological mechanisms of neuropathic pain, that is,
pain induced by injury or disease of the nervous system. Animal models of neuropathic pain …

Peripheral nerve injury due to trauma, disease, and certain toxins sometimes produces
abnormal (neuropathic) pain syndromes that are chronic and refractory to standard …