PDLIM7 Promotes Tumor Metastasis in Papillary Thyroid Carcinoma via Stabilizing Focal Adhesion Kinase Protein

F Yang, M Yang, Y Liu, C Zhou, Y Chen, J Wu, X Zhang… - Thyroid, 2024 - liebertpub.com
Background: As an actin cytoskeleton interactor, PDZ (postsynaptic density 65-discs large-
zonula occludens 1) and LIM (abnormal cell lineage 11-isket 1-mechanosensory abnormal …

PDLIM5 identified by label-free quantitative proteomics as a potential novel biomarker of papillary thyroid carcinoma

X Wei, Y Zhang, S Yu, S Li, W Jiang, Y Zhu, Y Xu… - Biochemical and …, 2018 - Elsevier
In order to better understand the mechanisms underlying the development of papillary
thyroid carcinoma (PTC), and to identify new potential biomarkers, high-resolution label-free …

Regulatory and Interacting Partners of PDLIM7 in Thyroid Cancer

K Rood, CR Yamauchi, U Sharma, RT Laxa, C Robins… - Current …, 2023 - mdpi.com
Enigma protein, encoded by the PDLIM7 gene, is overexpressed in thyroid cancer in a stage-
dependent manner, suggesting a potential involvement in the initiation and progression of …

[HTML][HTML] High expression of PDLIM5 facilitates cell tumorigenesis and migration by maintaining AMPK activation in prostate cancer

X Liu, L Chen, H Huang, JM Lv, M Chen, FJ Qu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract PDZ and LIM domain 5 (PDLIM5) is a cytoskeleton-associated protein and has
been shown to bind to a variety of proteins through its specific domain, thereby acting to …

PDZ and LIM domain protein 4 suppresses the growth and invasion of ovarian cancer cells via inactivation of STAT3 signaling

Y Jia, H Shi, Y Cao, W Feng, M Li, X Li - Life sciences, 2019 - Elsevier
Aims PDZ and LIM domain protein 4 (PDLIM4) is frequently repressed in cancer tissues.
However, the expression and role of PDLIM4 in ovarian cancer has not been addressed …

MALAT1 promotes the proliferation and invasion of thyroid cancer cells via regulating the expression of IQGAP1

J Huang, L Ma, W Song, B Lu, Y Huang, H Dong… - Biomedicine & …, 2016 - Elsevier
Background Increasing evidence indicated that metastasis-associated lung
adenocarcinoma transcript 1 (MALAT1) acted as a key regulator in the proliferation and …

High Expression of PDLIM2 Predicts a Poor Prognosis in Prostate Cancer and Is Correlated with Epithelial‐Mesenchymal Transition and Immune Cell Infiltration

S Piao, L Zheng, H Zheng, M Zhou… - Journal of …, 2022 - Wiley Online Library
Purpose. To elucidate the clinical and prognostic role of PDZ and LIM domain protein
(PDLIM) genes and the association to epithelial‐mesenchymal transition (EMT) and immune …

LIMD2 regulates key steps of metastasis cascade in papillary thyroid cancer cells via MAPK crosstalk

RP Araldi, TC de Melo, D Levy, DM de Souza… - Cells, 2020 - mdpi.com
Although papillary thyroid carcinoma (PTC) has a good prognosis, 20–90% of patients show
metastasis to regional lymph nodes and 10–15% of patients show metastasis to distant sites …

PDLIM2 can inactivate the TGF‐β/Smad pathway to inhibit the malignant behavior of ovarian cancer cells

W Lv, H Guo, J Wang, R Ma, L Niu… - Cell Biochemistry and …, 2023 - Wiley Online Library
PDZ‐LIM domain‐containing Protein 2 (PDLIM2) has been reported to be downregulated in
ovarian cancer. However, its exact function and mechanism in regulating ovarian cancer …

PDLIM2 and Its Role in Oncogenesis--Tumor Suppressor or Oncoprote?

J Maryáš, P Bouchal - Klinicka onkologie: casopis Ceske a …, 2015 - europepmc.org
PDZ and LIM domain containing protein 2 (PDLIM2), also known as Mystique or SLIM, is a
member of the actinin-associated LIM family of proteins that play essential roles in …