The present study examined whether the effect of stimulation of the nucleus raphe magnus
(NRM) is mediated by spinal cord dorsal horn serotonin1A (5-HT1A) receptors in the rat …

ABSTRACT The bulbospinal serotonin(5-HT) system is thought to suppress spinally
organized nociceptive reflexes by raising nociceptive thresholds. The present study …

The purpose of the present experiments was to determine whether serotonin-1A (5-HT 1A)
and serotonin-1B (5-HT 1B) binding sites, recently characterized in the spinal cord of the rat …

Serotonin (5-HT) plays a major yet complex role in modulating spinal nociceptive
transmission as a consequence of the number of 5-HT receptor subtypes. These include the …

The serotonin-containing raphe-spinal pathway has been implicated as playing an important
role in analgesia. Several studies, however, have reported the inefficacy of traditional …

The in vitro hemisected spinal cord from young rat was used to investigate the mechanism of
serotoninergic modulation of primary afferent‐mediated synaptic transmission in the dorsal …

We have developed a technique which allows drugs to be microinjected intrathecally in
anaesthetized rats whilst single unit recordings are made from dorsal horn neurones. Using …

The selective 5-HT 3 receptor agonist 2-methyl-serotonin (2-Me-5-HT) mimicked the
antinociceptive activity of 5-HT when intrathecally administered to rats. Two hundred μg (it) …

The antinociceptive role of spinal serotonin (5-HT) neurons descending from 5-HT cells near
the ventrolateral surface of the medulla oblongata was investigated by stimulating these …

The effects of 5-hydroxytryptamine on the membrane potential and input resistance of 86
dorsal horn neurons were studied using intracellular recordings in isolated, hemisected …