This study aims to explore the mechanism of glioblastoma multiforme (GBM) in hypoxia
through metabolomic and proteomic analysis. We showed that the migration and …

Glioblastoma (GBM) is a primary malignant tumor characterized by high infiltration and
angiogenesis in the brain parenchyma. Glioma stem cells (GSCs), a heterogeneous GBM …

Widespread invasiveness, represented by the invasion and migration, is the most important
characteristic of glioblastoma multiforme (GBM) and is the main reason for therapeutic …

Hypoxia, as an important hallmark of the tumor microenvironment, is a major cause of
oxidative stress and plays a central role in various malignant tumors, including glioblastoma …

Background Polarization of microglia cells in the glioma microenvironment is closely related
to the malignant progression and invasion of gliomas. Prolyl 4-hydroxylase subunit α1 …

Abstract HCLS1‐associated protein X‐1 (HAX1), an anti‐apoptotic molecular,
overexpresses in glioma. However, the role of HAX1 in glioma cell surviving in hypoxic …

Hypoxia contributes to the maintenance of stem-like cells in glioblastoma (GBM), and
activates vascular mimicry and tumor resistance to anti-angiogenesis treatments. The …

Abstract Background Prolyl 4-Hydroxylase Subunit Alpha 1 (P4HA1) is the active catalytic
component of prolyl 4-hydroxylase and plays a crucial role in modulating extracellular matrix …

Given its contribution to malignant phenotypes of cancer, tumor hypoxia has been
considered as a potential therapeutic problem. In the stressful microenvironment condition …

Gastric cancer (GC) is a common tumor‐associated lethal disease, and invasiveness and
metastasis are primary challenges in its clinical treatment. Hypoxia microenvironment …