The Klotho gene has been identified as an aging suppressor gene that encodes a
transmembrane protein, which is expressed primarily in renal tubules. There are 2 forms of …

Abstract Objective Soluble serum Klotho is a new biomarker linked to chronic kidney
disease, cardiovascular disease and diabetes. This study describes the evaluation and …

Background Klotho is a single-pass transmembrane protein, which appears to be implicated
in aging. The purpose of the present study was to characterize the relationship between the …

A novel gene, klotho (kl), which is involved in the development of a syndrome resembling
human aging in mice, was recently identified. The kl gene encodes a single-pass membrane …

Klotho in health and disease : Current Opinion in Nephrology and Hypertension Klotho in
health and disease : Current Opinion in Nephrology and Hypertension Log in or Register …

Klotho is a single‐pass transmembrane protein predominantly expressed in the kidney. The
extracellular domain of Klotho is subject to ectodomain shedding and is released into the …

OBJECTIVES: Both kidney expression and soluble serum Klotho are influenced by chronic
kidney disease (CKD) and diabetes. Serum Klotho is a yet poorly explored biomarker. We …

Background Klotho has been investigated as an anti-aging protein that is predominantly
expressed in the distal convoluted tubules in the kidneys and in the choroid plexus of the …

Background Klotho gene was identified as an aging suppressor. In animals, klotho
overexpression extends life span, and defective klotho results in rapid aging and early …

Aim To investigate the associations of serum α-Klotho and β-Klotho levels with type 2
diabetes mellitus (T2DM) progression. Methods We evaluated 106 healthy controls and 261 …