Bipolar, schizophrenia, and schizoaffective disorders are common, highly heritable
psychiatric disorders, for which familial coaggregation, as well as epidemiological and …

Genetic epidemiological studies reveal that relatives of bipolar probands are at increased
risk for recurrent unipolar, bipolar, and schizoaffective disorders, whereas relatives of …

Schizophrenic and bipolar disorders are similar in several epidemiologic respects, including
age at onset, lifetime risk, course of illness, worldwide distribution, risk for suicide, gender …

The relatively short history of linkage studies in bipolar disorders (BPs) has produced
inconsistent findings. Implicated regions have been large, with reduced levels of …

There is substantial evidence for partial overlap of genetic influences on schizophrenia and
bipolar disorder, with family, twin, and adoption studies showing a genetic correlation …

We conducted genomewide linkage analyses on 1,152 individuals from 250 families
segregating for bipolar disorder and related affective illnesses. These pedigrees were …

Objective: The purpose of this study was to assemble and validate a database of phenotypic
variables that were collected from families with bipolar disorder as a resource for genetic …

▪ Abstract Gene finding in genetically complex diseases has been difficult as a result of many
factors that have diagnostic and methodologic considerations. For bipolar disorder and …

The low-to-moderate resolution of linkage analysis in complex traits has underscored the
need to identify disease phenotypes with presumed genetic homogeneity. Bipolar disorder …

▪ Abstract Genetic epidemiologic studies reveal that relatives of bipolar (BIP) probands are at
increased risk for recurrent unipolar (RUP), BIP, and schizoaffective (SA) disorders, while …