Background The appropriate treatment for a sporadic endocrine tumour may be different
from those that present as part of the multiple endocrine neoplasia type 1 (MEN1) syndrome …

More than 50% of patients with typical MEN-2B have a de novo M918T germline mutation of
the RET protooncogene. However, even in typical MEN-2B, extrathyroidal manifestations of …

Nonfunctioning neuroendocrine tumors of the pancreas are rare slow-growing tumors with a
more indolent natural history compared with pancreatic adenocarcinoma. This retrospective …

Objective To determine the benefit of periodical clinical screening of carriers of a mutation in
the multiple endocrine neoplasia type 1 (MEN-1) gene, because any useful discussion …

Conclusions Currently, surgery for insulinoma is curative in nearly every patient, even those
with MEN1, and fu-ture direction seems to be to make it more cosmeti-cally acceptable and …

Zollinger–Ellison syndrome (ZES) is a clinical syndrome with severe peptic ulcer disease
and diarrhea caused by gastric acid hypersecretion secondary to a neuroendocrine tumour …

BACKGROUND: Neuroendocrine tumors of the gastrointestinal tract (carcinoids, pancreatic
endocrine tumors) have low malignant potential but can decrease survival rates if they …

Endoscopic ultrasound (EUS) enables detection and localization of pancreatic
neuroendocrine tumours. Even small tumours down to a diameter of 1–2 mm can be …

In patients with multiple endocrine neoplasia type 1 (MEN-1), gastrinomas are common and
thought to occur predominantly in the pancreas. We describe eight patients with MEN-1 and …

Radiologically demonstrable pancreatic endocrine tumors are a frequent requirement for
exploration in patients with multiple endocrine neoplasia type I (MEN-I). Such delayed …