Sepsis is a state of disrupted inflammatory homeostasis that is often initiated by infection.
The development and progression of sepsis is multi-factorial, and affects the cardiovascular …

Sepsis remains a major cause of morbidity and mortality mainly because of sepsis-induced
multiple organ dysfunction. In contrast to preclinical studies, most clinical trials of promising …

Objective: To postulate reasons as to why the benefits seen with novel therapies in animal
models of sepsis fail to translate to the clinical setting. Data Source: MEDLINE searches and …

Sepsis has been identified by the World Health Organization (WHO) as a global health
priority. There has been a tremendous effort to decipher underlying mechanisms …

Objective: To describe potential mechanisms that may account for the observation that drugs
that work in treating sepsis in animal models often fail in sepsis trials in patients. Data …

Introduction Sepsis is a complex inflammatory disorder believed to originate from an
infection by any types of microbes and/or their products. It is the leading cause of death in …

An extensive network of regulation of systemic inflammation makes development of a
reproducible experimental model of sepsis a complex task. There is no single mouse model …

Sepsis is a common clinical entity causing thousands of deaths and costing billions of
healthcare dollars annually in the US alone [1–4]. Further, sepsis and septic shock represent …

In the development of therapeutic strategies for human diseases, preclinical experimental
models have a key role. However, the preclinical immunomodulatory therapies developed …

Sepsis is a complex and heterogeneous syndrome defined by the systemic inflammatory
response to infection. 1 Development of organ failure leads to severe sepsis. Septic shock is …