Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway

P Guan, ZM Sun, N Wang, J Zhou, LF Luo, YS Zhao… - Life sciences, 2019 - Elsevier
Aims Resveratrol is a polyphenolic compound that has received much attention for its use in
ameliorating various systemic pathological conditions. The present study was performed to …

Resveratrol improves cardiac function and exercise performance in MI-induced heart failure through the inhibition of cardiotoxic HETE metabolites

N Matsumura, S Takahara, ZH Maayah… - Journal of molecular and …, 2018 - Elsevier
Numerous epidemiological studies have demonstrated that approximately 40% of
myocardial infarctions (MI) are associated with heart failure (HF). Resveratrol, a naturally …

Resveratrol ameliorates cardiac dysfunction induced by pressure overload in rats via structural protection and modulation of Ca2+ cycling proteins

Q Dong, Z Wu, X Li, J Yan, L Zhao, C Yang, J Lu… - Journal of translational …, 2014 - Springer
Background Cardiac hypertrophy is a compensatory stage of the heart in response to stress
such as pressure overload (PO), which can develop into heart failure (HF) if left untreated …

Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR pathway

J Song, Y Huang, W Zheng, J Yan, M Cheng… - Frontiers of …, 2018 - Springer
Oxidative stress induced by free fatty acid aggravates endothelial injury, which leads to
diabetic cardiovascular complications. Reduction of intracellular oxidative stress may …

[HTML][HTML] Resveratrol attenuated low ambient temperature-induced myocardial hypertrophy via inhibiting cardiomyocyte apoptosis

K Yin, L Zhao, D Feng, W Ma, Y Liu, Y Wang… - Cellular Physiology and …, 2015 - karger.com
Background/Aims: Low ambient temperature is an important risk factor for cardiovascular
diseases, and has been shown to lead to cardiac hypertrophy. In this study, we aim to …

[HTML][HTML] Resveratrol activates PI3K/AKT to reduce myocardial cell apoptosis and mitochondrial oxidative damage caused by myocardial ischemia/reperfusion injury

D Yu, J Xiong, Y Gao, J Li, D Zhu, X Shen, L Sun… - Acta …, 2021 - Elsevier
Resveratrol is a kind of iPolyphenols widely existing in herbal medicine. Here we aim to
investigate whether resveratrol can reduce the degree of myocardial ischemia/reperfusion …

Cardioprotective effect of resveratrol in a postinfarction heart failure model

A Riba, L Deres, B Sumegi, K Toth… - Oxidative medicine …, 2017 - Wiley Online Library
Despite great advances in therapies observed during the last decades, heart failure (HF)
remained a major health problem in western countries. In order to further improve symptoms …

Resveratrol attenuated hydrogen peroxide-induced myocardial apoptosis by autophagic flux

CY Huang, WJ Ting, CY Huang, JY Yang… - Food & nutrition …, 2016 - Taylor & Francis
Background Resveratrol is a Sirt-1-specific activator, which also exerts cardioprotective
effects that regulate redox signalling during oxidative stress and autophagy during …

STVNa attenuates isoproterenol-induced cardiac hypertrophy response through the HDAC4 and Prdx2/ROS/Trx1 pathways

F Liu, H Su, B Liu, Y Mei, Q Ke, X Sun… - International journal of …, 2020 - mdpi.com
Recent data show that cardiac hypertrophy contributes substantially to the overall heart
failure burden. Mitochondrial dysfunction is a common feature of cardiac hypertrophy …

[HTML][HTML] Inhibition of cardiomyocytes hypertrophy by resveratrol is associated with amelioration of endoplasmic reticulum stress

Y Lin, J Zhu, X Zhang, J Wang, W Xiao, B Li… - Cellular Physiology and …, 2016 - karger.com
Background/Aims: Resveratrol (Res), a polyphenol antioxidant found in red wine, has been
shown to play a cardioprotective role. This study was undertaken to investigate whether Res …