Serotonin signaling suppresses generation of amyloid-β (Aβ) in vitro and in animal models
of Alzheimer's disease (AD). We show that in an aged transgenic AD mouse model …

Aggregation of amyloid-β (Aβ) as toxic oligomers and amyloid plaques within the brain
appears to be the pathogenic event that initiates Alzheimer's disease (AD) lesions. One …

Background The aggregation of amyloid-β (Aβ) into insoluble plaques is a hallmark
pathology of Alzheimer's disease (AD). Previous work has shown increasing serotonin …

Background Several neurotransmitter receptors activate signaling pathways that alter
processing of the amyloid precursor protein (APP) into β-amyloid (Aβ). Serotonin signaling …

The amyloid hypothesis suggests that the progressive accumulation and deposition of
central nervous system (CNS) amyloid with aging is the proximate cause of Alzheimer's …

Given the failure to develop disease-modifying therapies for Alzheimer's disease (AD),
strategies aiming at preventing or delaying the onset of the disease are being prioritized …

Besides the memory impairment, Alzheimer's disease (AD) is often complicated by
neuropsychiatric symptoms also known as behavioral and psychological symptoms of …

Amyloid β (Aβ) accumulation is considered the main culprit in the pathogenesis of
Alzheimer's disease (AD). Recent studies suggest that decreasing Aβ production at very …

To better understand amyloid‐β (Aβ) metabolism in vivo, we assessed the concentration of
Aβ in the CSF and plasma of APPV717F (PDAPP) transgenic mice, a model that develops …

Alzheimer's disease (AD) is characterized by a microglial-mediated inflammatory response
elicited by extensive amyloid deposition in the brain. Nonsteroidal anti-inflammatory drug …