A scientific highlight of the first half of the twentieth century was the discovery and
characterization of many biologically active molecules. Many large (hormones …

Several aspects of our 25 year adventure in the field of tachykinins will be successively
described. They concern: substance P (SP) synthesis and release in the basal ganglia, the …

Publisher Summary This chapter focuses on the progress in the development of neurokinin
(NK) antagonists. The neurokinins substance P (SP), neurokinin A (NKA), and neurokinin B …

The tachykinins are a group of structurally related peptides found in many regions of the
nervous system including brain and spinal cord, intrinsic neurons of the intestine, and …

The involvement of tachykinin neuropeptides, such as substance P and the neurokinins, in
pain transmission is supported by a wealth of evidence. At present. the therapeutic potential …

Studies on tachykinin peptides and the corresponding neurokinin receptors (NKr) have
increased dramatically recently due to the discovery of selective, orally-active, metabolically …

The tachykinins, exemplified by substance P, are one of the most intensively studied
neuropeptide families. They comprise a series of structurally related peptides that derive …

Molecular aspects of the tachykinin receptors Page 1 Regulatory Peptides, 43 (1993) 21-35
21 й 1993 Elsevier Science Publishers BV All rights reserved 0167-0115/93/$06.00 …

The three mammalian tachykinins, substance P (SP), neurokinin A (NKA) and neurokinin B
(NKB), exert their physiological effects through specific receptors, NK1, NK2 and NK3 …

Offers a state-of-the-art review by international experts on all aspects of tachykinin receptors,
including neuropeptide/peptide and G-protein-linked receptors in general. It covers the …