A new class of high affinity ligands for the neurokinin A NK2 receptor:. psi.(CH2NR) reduced peptide bond analogs of neurokinin A4-10
SL Harbeson, SA Shatzer, TB Le… - Journal of medicinal …, 1992 - ACS Publications
The tachykinins are a family of peptides containing the C-terminal sequence Phe-Xxx-Gly-
Leu-Met-NH2. The mammalian tachykinins, substance P, neurokinin A, and neurokinin B …
Leu-Met-NH2. The mammalian tachykinins, substance P, neurokinin A, and neurokinin B …
Antagonists for the neurokinin NK-3 receptor evaluated in selective receptor systems
G Drapeau, N Rouissi, F Nantel, NE Rhaleb… - Regulatory peptides, 1990 - Elsevier
Four isolated vessels that are monoreceptor systems for neurokinins, the dog carotid artery
and rabbit jugular vein (NK-1), the rabbit pulmonary artery (NK-2) and the rat portal vein (NK …
and rabbit jugular vein (NK-1), the rabbit pulmonary artery (NK-2) and the rat portal vein (NK …
[PDF][PDF] Both extracellular and transmembrane residues contribute to the species selectivity of the neurokinin-1 receptor antagonist WIN 51708
BS Sachais, JE Krause - Molecular pharmacology, 1994 - Citeseer
SUMMARY WIN 51 708 is a nonpeptide antagonist of the neurokinin(NK)-1 (substance P)
receptor that possesses a dramatically higher affinity for the rat NK-1 receptor, compared …
receptor that possesses a dramatically higher affinity for the rat NK-1 receptor, compared …
Pharmacological characterization of ZD6021: a novel, orally active antagonist of the tachykinin receptors
WL Rumsey, D Aharony, RA Bialecki, BM Abbott… - … of Pharmacology And …, 2001 - ASPET
The tachykinins, substance P, neurokinin A, and neurokinin B, have been implicated in
many diseases. The present study evaluated the pharmacological properties of a novel …
many diseases. The present study evaluated the pharmacological properties of a novel …
[PDF][PDF] SR 48968, a neurokinin A (NK2) receptor antagonist
X Emonds-Alt, C Advenier, T Croci, L Manara… - Regulatory …, 1993 - academia.edu
Neurokinin A (NKA) belongs to a group of neuropeptides (tachykinins), that includes
substance-P (SP) and neurokinin B (NKB)[1] NKA induces the contraction of smooth …
substance-P (SP) and neurokinin B (NKB)[1] NKA induces the contraction of smooth …
Identification of a tachykinin NK2 receptor splice variant and its expression in human and rat tissues
ML Candenas, CG Cintado, JN Pennefather… - Life sciences, 2002 - Elsevier
The tachykinins substance P, neurokinin A and neurokinin B are implicated in different
diseases and play an important role in neuroimmunomodulation. These peptides interact …
diseases and play an important role in neuroimmunomodulation. These peptides interact …
Medicinal chemistry of selective neurokinin-1 antagonists
JM Humphrey - Current topics in medicinal chemistry, 2003 - ingentaconnect.com
The study of tachykinin NK1 (substance P) receptor antagonists has emerged as a field of
great promise due to accumulating evidence that NK1 antagonists offer possible new …
great promise due to accumulating evidence that NK1 antagonists offer possible new …
Stable expression of high affinity NK1 (substance P) and NK2(neurokinin A) receptors but low affinity NK3 (neurokinin B) receptors in transfected CHO cells
U Gether, T Marray, TW Schwartz, TE Johansen - FEBS letters, 1992 - Wiley Online Library
Stable CHO cell clones which selectively express all three rat tachykinin receptors were
established by transfection. The binding of radiolabeled substance P and neurokinin A …
established by transfection. The binding of radiolabeled substance P and neurokinin A …
[HTML][HTML] Chimeric NK1 (substance P)/NK3 (neurokinin B) receptors. Identification of domains determining the binding specificity of tachykinin agonists.
U Gether, TE Johansen, TW Schwartz - Journal of Biological Chemistry, 1993 - Elsevier
The NK1 (substance P) and NK3 (neurokinin B) receptors are G protein-coupled receptors
sharing approximately 70% identity within the membrane-spanning domains. However, they …
sharing approximately 70% identity within the membrane-spanning domains. However, they …
Pharmacological properties of peptides derived from an antibody against the tachykinin NK1 receptor for the neuropeptide substance P
A Wijkhuisen, S Tymciu, J Fischer… - European journal of …, 2003 - Elsevier
Two peptides were derived from the structural analysis of a previously described
monoclonal antibody [Mol. Immunol. 37 (2000) 423] against the tachykinin NK1 receptor for …
monoclonal antibody [Mol. Immunol. 37 (2000) 423] against the tachykinin NK1 receptor for …