The effects on the steady‐state digoxin pharmacokinetics of verapamil (240 mg/day) and a
new dihydropyridine calcium channel blocker, isradipine (15 mg/day), were compared …

Conflicting conclusions have been reported about interaction of calcium channel blockers
with digoxin. The effects of verapamil (240 mg/day) and a new dihydropyridine calcium …

To explore a possible interaction between digoxin and verapamil, a single‐dose kinetic
study of digoxin was performed and then repeated after 10 days of verapamil treatment in …

Single-dose investigations in healthy subjects have demonstrated substantial impairment of
renal and extrarenal clearance of digoxin during coadministration of verapamil. A …

A significant drug interaction between verapamil and digoxin, resulting in elevated serum
digoxin concentrations, has been well documented in the medical literature. However, a …

The pharmacokinetics of digoxin were studied before and after a 2 week course of diltiazem,
30 mg four times daily, in 7 healthy volunteers. Each subject received an IV dose of digoxin …

The influence of several calcium antagonists and antiarrhythmic drugs on digoxin kinetics
and actions were investigated in 36 healthy men during digoxin steady state (0.375 mg/day) …

Six subjects were evaluated for the effect of quinine, the 1‐isomer of quinidine, on digoxin
pharmacokinetics. A 1.0‐mg intravenous digoxin dose was given before and during quinine …

In order to explore the digoxin‐quinine interaction, digoxin steady state pharmacokinetics
was studied before and during quinine coadministration in seven healthy subjects. Quinine …