Background Alzheimer's disease (AD) is a progressive neurodegenerative brain disorder
that is characterized by dementia, cognitive impairment, and memory loss. Diverse factors …

The most frequent type of age-related dementia is Alzheimer's disease. To discover novel
therapeutic agents for Alzheimer's disease, a series of substituted pyrimidine derivatives …

Alzheimer's disease (AD), a multifactorial complex neural disorder, is categorized with
progressive memory loss and cognitive impairment as main clinical features. The multitarget …

Introduction: Recent decades have witnessed the growing interest in the development of
imidazoline derivatives in drug discovery due to increased knowledge in pathogenesis of …

Alzheimer's disease (AD) is the most common form of dementia with no cure so far, probably
due to the complexity of this multifactorial disease with diverse processes associated with its …

This study describes the synthesis, pharmacological evaluation, including
acetylcholinesterase (AChE)/butyrylcholinesterase (BChE) inhibition, amyloid beta (Aβ) …

The strategy of the nucleophilic substitution of hydrogen (SNH) was first applied for the metal-
free CH/CH coupling reactions of 4 H-imidazole 3-oxides with indoles. As a result, a series …

Imidazoline receptors historically referred to a family of nonadrenergic binding sites that
recognize compounds with an imidazoline moiety, although this has proven to be an …

Relationship between biological responses and binding affinities at I1/I2/I3 imidazoline
receptors of compounds with imidazoline, pyrroline or oxazoline moieties was studied by 2D …

Alzheimer's Disease (AD) is one of the commonest neural degenerations in an aging
population, and has become a global health challenge. 2-(2-benzofuranyl)-2-imidazoline (2 …