Risk for Atrial Fibrillation (AF), the most common human arrhythmia, has a major genetic
component. The T-box transcription factor TBX5 influences human AF risk, and adult-specific …

Heart development and rhythm control are highly Tbx5 dosage-sensitive. TBX5
haploinsufficiency causes congenital conduction disorders, whereas increased expression …

Aims Atrial fibrillation (AF) is a common arrhythmia with an important heritable aspect. The
genetic factors underlying AF have not been fully elucidated. Methods and results We …

TBX3 is critical for human development: mutations in TBX3 cause congenital anomalies in
patients with ulnar-mammary syndrome. Data from mice and humans suggest multiple roles …

Aims Arrhythmias and sudden cardiac death (SCD) occur commonly in patients with heart
failure. We found T-box 5 (TBX5) dysregulated in ventricular myocardium from heart failure …

Human mutations in or variants of TBX20 are associated with congenital heart disease,
cardiomyopathy, and arrhythmias. To investigate whether cardiac disease in patients with …

Atrial fibrillation (AF), defined by disorganized atrial cardiac rhythm, is the most prevalent
cardiac arrhythmia worldwide. Recent genetic studies have highlighted a major heritable …

Background: The pathogenic missense variant p. G125R in TBX5 (T-box transcription factor
5) causes Holt–Oram syndrome (also known as hand–heart syndrome) and early onset of …

Previous genome-wide association studies have demonstrated that single nucleotide
polymorphisms in T‑box (TBX) 5 are associated with increased susceptibility to atrial …

Atrial fibrillation (AF), the most common type of cardiac rhythm disturbance encountered in
clinical practice, is associated with substantially increased morbidity and mortality …