Moderate hyperhomocysteinemia decreases endothelial-dependent vasorelaxation in pregnant but not nonpregnant mice

RW Powers, RE Gandley, DL Lykins, JM Roberts - Hypertension, 2004 - Am Heart Assoc
Increased homocysteine is associated with the pregnancy complication preeclampsia and
with later-life cardiovascular disease. Although elevated homocysteine persists after …

[HTML][HTML] Hyperhomocysteinemia is detrimental to pregnancy in mice and is associated with preterm birth

SR Sonne, VK Bhalla, SA Barman, RE White… - … et Biophysica Acta (BBA …, 2013 - Elsevier
Elevated levels of homocysteine produce detrimental effects in humans but its role in
preterm birth is not known. Here we used a mouse model of hyperhomocysteinemia to …

Homocysteine inhibits extra‐embryonic vascular development in the avian embryo

KS Latacha, TH Rosenquist - Developmental dynamics: an …, 2005 - Wiley Online Library
A strong association exists between pregnancy loss and maternal elevations of the sulfur‐
containing amino acid, homocysteine. Because extra‐embryonic vascular growth is critical …

Preeclampsia-like features and partial lactation failure in mice lacking cystathionine γ-lyase—an animal model of cystathioninuria

N Akahoshi, H Handa, R Takemoto, S Kamata… - International Journal of …, 2019 - mdpi.com
Elevated plasma homocysteine levels are considered as a risk factor for cardiovascular
diseases as well as preeclampsia—a pregnancy disorder characterized by hypertension …

Endothelial dysfunction in a murine model of mild hyperhomocyst (e) inemia

RT Eberhardt, MA Forgione, A Cap… - The Journal of …, 2000 - Am Soc Clin Investig
Homocysteine is a risk factor for the development of atherosclerosis and its thrombotic
complications. We have employed an animal model to explore the hypothesis that an …

Homocysteine, cysteine, and related metabolites in maternal and fetal plasma in preeclampsia

K Braekke, PM Ueland, NK Harsem, A Karlsen… - Pediatric …, 2007 - nature.com
Homocysteine is associated with endothelial dysfunction and cardiovascular disease, and
elevated concentrations of homocysteine have been found in preeclampsia. The purpose of …

Plasma homocysteine concentration is increased in preeclampsia and is associated with evidence of endothelial activation

RW Powers, RW Evans, AK Majors, JI Ojimba… - American journal of …, 1998 - Elsevier
Objective: We tested the hypothesis that the independent risk factor for atherosclerosis of
increased plasma homocysteine concentration is associated with the pregnancy syndrome …

Hypertension in pregnancy is associated with elevated homocysteine levels later in life

WM White, ST Turner, KR Bailey, TH Mosley Jr… - American journal of …, 2013 - Elsevier
Objective Hyperhomocysteinemia is associated with an elevated cardiovascular disease
risk. We examined whether women with a history of hypertension in pregnancy are more …

Hyperhomocysteinemia in pregnant rats: Effects on arterial pressure, kidneys and fetal growth

SE Kassab, MF Abu-Hijleh, HB Al-Shaikh… - European Journal of …, 2005 - Elsevier
OBJECTIVE:: This study aimed to test the hypothesis that hyperhomocysteinemia plays a
role in the development of pathological changes similar to human preeclampsia in pregnant …

Hyperhomocysteinemia impairs endothelium-derived hyperpolarizing factor–mediated vasorelaxation in transgenic cystathionine beta synthase–deficient mice

Z Cheng, X Jiang, WD Kruger, D Praticò… - Blood, The Journal …, 2011 - ashpublications.org
Hyperhomocysteinemia (HHcy) is associated with endothelial dysfunction (ED), but the
mechanism is largely unknown. In this study, we investigated the role and mechanism of …