Moderate hyperhomocysteinemia decreases endothelial-dependent vasorelaxation in pregnant but not nonpregnant mice
RW Powers, RE Gandley, DL Lykins, JM Roberts - Hypertension, 2004 - Am Heart Assoc
Increased homocysteine is associated with the pregnancy complication preeclampsia and
with later-life cardiovascular disease. Although elevated homocysteine persists after …
with later-life cardiovascular disease. Although elevated homocysteine persists after …
[HTML][HTML] Hyperhomocysteinemia is detrimental to pregnancy in mice and is associated with preterm birth
SR Sonne, VK Bhalla, SA Barman, RE White… - … et Biophysica Acta (BBA …, 2013 - Elsevier
Elevated levels of homocysteine produce detrimental effects in humans but its role in
preterm birth is not known. Here we used a mouse model of hyperhomocysteinemia to …
preterm birth is not known. Here we used a mouse model of hyperhomocysteinemia to …
Homocysteine inhibits extra‐embryonic vascular development in the avian embryo
KS Latacha, TH Rosenquist - Developmental dynamics: an …, 2005 - Wiley Online Library
A strong association exists between pregnancy loss and maternal elevations of the sulfur‐
containing amino acid, homocysteine. Because extra‐embryonic vascular growth is critical …
containing amino acid, homocysteine. Because extra‐embryonic vascular growth is critical …
Preeclampsia-like features and partial lactation failure in mice lacking cystathionine γ-lyase—an animal model of cystathioninuria
N Akahoshi, H Handa, R Takemoto, S Kamata… - International Journal of …, 2019 - mdpi.com
Elevated plasma homocysteine levels are considered as a risk factor for cardiovascular
diseases as well as preeclampsia—a pregnancy disorder characterized by hypertension …
diseases as well as preeclampsia—a pregnancy disorder characterized by hypertension …
Endothelial dysfunction in a murine model of mild hyperhomocyst (e) inemia
RT Eberhardt, MA Forgione, A Cap… - The Journal of …, 2000 - Am Soc Clin Investig
Homocysteine is a risk factor for the development of atherosclerosis and its thrombotic
complications. We have employed an animal model to explore the hypothesis that an …
complications. We have employed an animal model to explore the hypothesis that an …
Homocysteine, cysteine, and related metabolites in maternal and fetal plasma in preeclampsia
K Braekke, PM Ueland, NK Harsem, A Karlsen… - Pediatric …, 2007 - nature.com
Homocysteine is associated with endothelial dysfunction and cardiovascular disease, and
elevated concentrations of homocysteine have been found in preeclampsia. The purpose of …
elevated concentrations of homocysteine have been found in preeclampsia. The purpose of …
Plasma homocysteine concentration is increased in preeclampsia and is associated with evidence of endothelial activation
RW Powers, RW Evans, AK Majors, JI Ojimba… - American journal of …, 1998 - Elsevier
Objective: We tested the hypothesis that the independent risk factor for atherosclerosis of
increased plasma homocysteine concentration is associated with the pregnancy syndrome …
increased plasma homocysteine concentration is associated with the pregnancy syndrome …
Hypertension in pregnancy is associated with elevated homocysteine levels later in life
WM White, ST Turner, KR Bailey, TH Mosley Jr… - American journal of …, 2013 - Elsevier
Objective Hyperhomocysteinemia is associated with an elevated cardiovascular disease
risk. We examined whether women with a history of hypertension in pregnancy are more …
risk. We examined whether women with a history of hypertension in pregnancy are more …
Hyperhomocysteinemia in pregnant rats: Effects on arterial pressure, kidneys and fetal growth
SE Kassab, MF Abu-Hijleh, HB Al-Shaikh… - European Journal of …, 2005 - Elsevier
OBJECTIVE:: This study aimed to test the hypothesis that hyperhomocysteinemia plays a
role in the development of pathological changes similar to human preeclampsia in pregnant …
role in the development of pathological changes similar to human preeclampsia in pregnant …
Hyperhomocysteinemia impairs endothelium-derived hyperpolarizing factor–mediated vasorelaxation in transgenic cystathionine beta synthase–deficient mice
Hyperhomocysteinemia (HHcy) is associated with endothelial dysfunction (ED), but the
mechanism is largely unknown. In this study, we investigated the role and mechanism of …
mechanism is largely unknown. In this study, we investigated the role and mechanism of …