Objective. To evaluate the safety and immunogenicity of the recombinant acellular
pertussisdiphtheria-tetanus (aPDT) vaccine (C-aPDT, Chiron/Biocine®). Study design. This …

Background. The high reactogenicity of whole cell pertussis vaccines discourages their use
in children. While acellular pertussis vaccines are less reactogenic, their use in diphtheria …

The objective of this open study was to monitor the long-term effectiveness of the Lederle-
Takeda diphtheria and tetanus toxoids and acellular pertussis antigen (s)(DTaP) vaccine …

Objective. To compare the immunogenicity and reactogenicity of a diphtheria and tetanus
toxoids and three-component acellular pertussis vaccine (DTaP) with a diphtheria and …

Background. The goal of the trial was to determine the efficacy of a multicomponent acellular
pertussis vaccine against Bordetella illnesses in comparison with a whole-cell product and …

Background Reduced-antigen-content tetanus, diphtheria, and acellular pertussis (Tdap)
vaccine is recommended in many countries for boosting immunity in adolescents and adults …

Many countries recommend diphtheria, tetanus and/or poliomyelitis boosters in adolescents
or adults and the need for pertussis booster vaccination beyond childhood is increasingly …

• An acellular pertussis—component diphtheria-tetanus-pertussis (AC-DTP) vaccine was
compared with a currently licensed, whole-cell pertussis—component DTP (WC-DTP) …

Objective. Diphtheria, tetanus and pertussis serum antibody titers were assessed before a
fifth dose of diphtheria-tetanus-acellular pertussis (DTaP) or diphtheria-tetanus-whole cell …

A new five-component acellular pertussis (AP) vaccine containing 10 µLg of pertussis toxoid,
S µg of filamentous hemagglutinin, 5 jµ of combined agglutinogens 2 and 3, and 3 µg of …