We analyze the interactions between division, mutation and selection in a simplified
evolutionary model, assuming that the population observed can be classified into fitness …

The humoral immune response to antigenic challenge involves a Darwinian process of
somatic mutations and selection for B-cells carrying higher affinity antibodies. Insufficient …

Lymphocyte selection is a fundamental process of adaptive immunity. In order to produce B-
lymphocytes with a target antigenic profile, mutation selection and division occur in the …

Mathematical modeling of complex biological systems has been shown to lead to
contradictory results. Two completely different approaches are compared using a highly …

We present a model that considers the maturation of the antibody population following
primary antigen presentation as a global optimization problem. The trade-off that emerges …

Affinity maturation of antibodies during immune responses is achieved by multiple rounds of
somatic hypermutation and subsequent preferential selection of those B cells that express B …

We propose a stochastic framework to describe the evolution of the B-cell repertoire during
germinal center (GC) reactions. Our model is formulated as a multitype age-dependent …

During the immune response, the generation of memory B lymphocytes in germinal centers
involves affinity maturation of the cells' antigen receptors, based on somatic hypermutation …

We study the maturation of the antibody population following primary antigen presentation
as a global optimization problem. Emphasis is placed on the trade-off between the safety of …

The population dynamics theory of B cells in a typical germinal center could play an
important role in revealing how affinity maturation is achieved. However, the existing models …