Optimization of antibody affinity is a hallmark of the humoral immune response. It takes place
in hundreds of transient microstructures called germinal centers (GCs). Their function and …

During development, spatio-temporal patterns ranging from checkerboard to engulfing occur
with precise proportions of the respective cell fates. Key developmental regulators are …

We use statistical mechanical techniques to model the adaptive immune system,
represented by lymphocyte networks in which B cells interact with T cells and antigen. We …

Here we present a mathematical model for the dynamics of oncogenesis control in mature T-
cell populations within the blood and lymphatic system. T-cell homeostasis is maintained by …

During the past century, mathematical modelling of biological processes rapidly developed
into a field of high scientific interest. The diversity of mathematical approaches and …

Antibody (Ab) affinity maturation (AAM) referred originally to the observed increase in
average Ab affinity against a hapten (1). Later, it was found that AAM is associated with the …

We consider the mutual interactions, via cytokine exchanges, among helper lymphocytes, B
lymphocytes and killer lymphocytes, and we model them as a unique system by means of a …

The immune response to an acute primary infection is a coupled process of antigen
proliferation, molecular recognition by naive B cells, and their subsequent proliferation and …

We investigate the temporal evolution of the distribution of immunities in a population, which
is determined by various epidemiological, immunological, and demographical phenomena …

We study stochastic evolutionary game dynamics in a population of finite size. Individuals in
the population are divided into two dynamically evolving groups. The structure of the …