Neuropathic pain therapy: a puzzle of different approaches to stratify patients

J Sachau, R Baron - Pain, 2021 - journals.lww.com
In recent years, more and more effort has been invested in the identification of biomarkers
for the treatment of neuropathic pain. Given the fact that many clinical trials on development …

Individualized neuropathic pain therapy based on phenotyping: are we there yet?

J Forstenpointner, J Otto, R Baron - Pain, 2018 - journals.lww.com
Patients with the same neuropathic pain disorder may have completely different sensory
signs and symptoms yet receive the same medicinal treatment. New concepts suggest that …

Personalized treatment of neuropathic pain: Where are we now?

D Bouhassira, N Attal - European Journal of Pain, 2023 - Wiley Online Library
Background The treatment of neuropathic pain remains a major unmet need that the
development of personalized and refined treatment strategies may contribute to address …

Sensory testing might not be perfect–but it is the best biomarker for pain phenotypes we have right now

J Vollert - Scandinavian Journal of Pain, 2022 - degruyter.com
Currently available treatments for neuropathic pain fail in roughly half of the patients–and it
is impossible to predict which treatments will help patients. Stratification of neuropathic pain …

Phenotyping neuropathic pain patients: implications for individual therapy and clinical trials

M Reimer, SM Helfert, R Baron - Current opinion in supportive …, 2014 - journals.lww.com
The discussed trials show the importance of the development of an individualized pain
therapy. Up to now, no clinical trial has prospectively used the sensory phenotype as an …

Evaluation of symptom heterogeneity in neuropathic pain using assessments of sensory functions

K Arning, R Baron - Neurotherapeutics, 2009 - Springer
Classification of neuropathic pain has been based on disease entities, anatomical
localization, or histological observations. Over the past decade, there has been an explosion …

Individualized pharmacological treatment of neuropathic pain

SM Helfert, M Reimer, J Höper… - Clinical Pharmacology & …, 2015 - Wiley Online Library
Patients with the same disease may suffer from completely different pain symptoms yet
receive the same drug treatment. Several studies elucidate neuropathic pain and treatment …

Precision medicine in neuropathic pain

J Sachau, R Baron - Precision Medicine, 2023 - Springer
Neuropathic pain is a common chronic pain condition that is caused by a lesion or disease
of the somatosensory nervous system. The multitude of sensory negative and positive …

Sensory profiles: a new strategy for selecting patients in treatment trials for neuropathic pain

G Cruccu, A Truini - Pain, 2009 - journals.lww.com
Unlike the plethora of drugs available to treat epilepsy, depression, or migraine,
comparatively few and insufficiently effective drugs are available for neuropathic pain …

Neuropathic pain: a clinical perspective

R Baron - Sensory Nerves, 2009 - Springer
Neuropathic pain syndromes, ie, pain after a lesion or disease of the peripheral or central
nervous system, are clinically characterized by spontaneous pain (ongoing, paroxysms) and …