Synthesis Strategies for α‐, β‐, γ‐and δ‐Carbolines

H Zhang, RH Zhang, LX Wang, YJ Li… - Asian Journal of …, 2021 - Wiley Online Library
Carbolines are widely present in various natural products and biological molecules.
Numerous studies have shown the broad biological activities of these heterocyclic motifs …

Synthesis of 1-indolyl substituted β-carboline natural products and discovery of antimalarial and cytotoxic activities

LPP Liew, JM Fleming, A Longeon, E Mouray, I Florent… - Tetrahedron, 2014 - Elsevier
A series of 1-indolyl substituted β-carbolines including the natural products
hyrtiosulawesine, pityriacitrin and pityriacitrin B were prepared via Pictet–Spengler …

An overview on synthetic entries to tetrahydro-β-carbolines

P Maity, D Adhikari, AK Jana - Tetrahedron, 2019 - Elsevier
The tetrahydro-β-carboline (THBC) nucleus is a predominant feature of a vast array of
naturally occurring alkaloids. Most of these alkaloids have been found to exhibit significant …

β-Carboline alkaloids: biochemical and pharmacological functions

R Cao, W Peng, Z Wang, A Xu - Current medicinal chemistry, 2007 - ingentaconnect.com
β-Carboline alkaloids are a large group of natural and synthetic indole alkaloids with
different degrees of aromaticity, some of which are widely distributed in nature, including …

1 (3)‐Formyl‐β‐carbolines: Potential Aldo‐X Precursors for the Synthesis of β‐Carboline‐Based Molecular Architectures

N Devi, S Kumar, SK Pandey… - Asian Journal of Organic …, 2018 - Wiley Online Library
Abstract β‐Carboline, a privileged scaffold in the alkaloid family, has a broad spectrum of
medicinal properties and is found in several commercial drugs, such as tadalafil …

Recent insights into synthetic β-carbolines with anti-cancer activities

S Kumar, A Singh, K Kumar, V Kumar - European Journal of Medicinal …, 2017 - Elsevier
Cancer, an uncontrolled and rapid proliferation of abnormal cells, has become one of the
leading cause of death worldwide. The development of resistance among the numerous …

A review of synthetic bioactive tetrahydro-β-carbolines: A medicinal chemistry perspective

J Wang, F Gong, T Liang, Z Xie, Y Yang, C Cao… - European Journal of …, 2021 - Elsevier
Abstract 1, 2, 3, 4-Tetrahydro-β-carboline (THβC) scaffold is widespread in many natural
products (NPs) and synthetic compounds which show a variety of pharmacological activities …

1-Formyl-9H-β-Carboline: A Useful Scaffold for Synthesizing Substituted-and Fused β-Carbolines

V Singh, S Batra - Current Organic Synthesis, 2012 - ingentaconnect.com
1-Formyl-9H-β-Carboline: A Useful Scaffold for Synthesizing Substituted- and Fused β-Carbolines§
Page 1 Current Organic Synthesis, 2012, 9, 513-528 513 1-Formyl-9H-β-Carboline: A Useful …

Comprehensive review of α-carboline alkaloids: Natural products, updated synthesis, and biological activities

D Li, R Yang, J Wu, B Zhong, Y Li - Frontiers in Chemistry, 2022 - frontiersin.org
α-carboline (9 H-pyrido [2, 3-b] indole), contains a pyridine ring fused with an indole
backbone, is a promising scaffold for medicinal chemistry. In recent decades, accumulating …

Preparation and antiprotozoal evaluation of promising β-carboline alkaloids

A Gellis, A Dumètre, S Hutter, E Ollivier… - Biomedicine & …, 2012 - Elsevier
The synthesis of β-carbolines and their in vitro antiplasmodial and antileishmanial activities
were described herein. These molecules have also been studied concerning their in vitro …