Carbolines are a prominent class of tricyclic alkaloids omnipresent in natural products and
bioactive compounds. Four different carboline regioisomers are known (α‐, β‐, γ‐, and δ …

To further our SAR study on the chemistry and antitumor activity/neurotoxicity of β-carboline
alkaloids, several series of β-carboline derivatives with various substituents were designed …

Since the first reported synthesis of an α-carboline almost a century ago, there has been a
steady interest in the development of strategies towards this unique heterocyclic motif. This …

Carbolines are among the most intriguing alkaloids and are classified according to their
position of N in the skeleton as α-, β-, γ-, or δcarbolines [1]. The γ-Carboline alkaloids show …

Functionalization of β-carbolines is a challenge as numerous natural alkaloids with different
biological activities present this heterocycle. The RCM is used herein with allyl-, vinyl …

The β-carboline alkaloids possess a wide diversity of important biochemical effects and
pharmacological properties. A series of β-carboline derivatives were synthesized from L …

δ-Carboline and its naturally obtained analogs are of importance due to their wide range of
biological properties. In the present review, we intend to discuss the main trends in the …

Substitution of chlorine in 5-chloro-N-phenylpyrazine-2-carboxamide (1) with simple n-
alkylamines yielded a series of 5-alkylamino-N-phenylpyrazine-2-carboxamides …

Indole-based alkaloids are well-known in the literature for their diverse biological properties.
Polysubstituted optically active tetrahydro-β-carboline derivatives functionalized on C-1 …

Abstract β‐Carbolines are present in a wide variety of indole alkaloids that display important
biological activities. Here we review the most recent aspects of the chemistry of β‐carbolines …