Synthesis and antimycobacterial evaluation of substituted pyrazinecarboxamides

M Dolezal, P Cmedlova, L Palek, J Vinsova… - European journal of …, 2008 - Elsevier
Unsubstituted, halogenated and/or alkylated pyrazine-2-carboxylic acid amides connected
via–CONH–bridge with substituted anilines were synthesized using currently known …

Synthesis and anti-Mycobacterium tuberculosis activity of imide-β-carboline and carbomethoxy-β-carboline derivatives

MA Lopes-Ortiz, MR Panice, EB de Melo… - European Journal of …, 2020 - Elsevier
A series of methyl β-carboline carboxylates (2a-g) and of imide-β-carboline derivatives
containing the phthalimide (4a-g), maleimide (5b, g) and succinimide (6b, e, g) moiety were …

Design, synthesis and anti-mycobacterial evaluation of some new iV-phenylpyrazine-2-carboxamides

J Zitko, SV Barbora, P Paterová, L Navrátilová… - Chemical …, 2016 - degruyter.com
Abstract N-Phenylpyrazine-2-carboxamides (anilides of pyrazinoic acids with simple
substituents in various positions) were previously shown to possess significant biological …

Synthesis and in vitro cytotoxic evaluation of 1, 3-bisubstituted and 1, 3, 9-trisubstituted β-carboline derivatives

R Cao, W Peng, H Chen, X Hou, H Guan… - European journal of …, 2005 - Elsevier
A series of novel 1, 3-bisubstituted and 1, 3, 9-trisubstituted β-carboline derivatives was
synthesized from the starting material l-tryptophan. Cytotoxic activities of these compounds …

Synthesis and biological evaluation of a novel class of β-carboline derivatives

H Chen, P Gao, M Zhang, W Liao, J Zhang - New Journal of Chemistry, 2014 - pubs.rsc.org
In this study, several novel β-carboline derivatives, 1-(4-hydroxy-3-methoxyphenyl)-β-
carboline-3-carboxyl-Trp-Trp-AA-OBzl compounds, were designed and synthesized as …

Design, synthesis and bio-evaluation of C-1 alkylated tetrahydro-β-carboline derivatives as novel antifungal lead compounds

R Singh, A Jaisingh, IK Maurya, DB Salunke - Bioorganic & Medicinal …, 2020 - Elsevier
The field of antifungal agent has become static and development of resistance by the
pathogen as well as limited clinical efficacy of marketed drugs demand the constant …

Synthesis of novel 1,2,3-triazole tethered 1,3-disubstituted β-carboline derivatives and their cytotoxic and antibacterial activities

P Salehi, K Babanezhad-Harikandei… - Medicinal Chemistry …, 2016 - Springer
In this paper new β-carboline derivatives possessing the 1, 2, 3-triazole ring at C-1
substituent were synthesized from L-tryptophan by Pictet–Spengler reaction followed by a …

An updates: Oxidative aromatization of THβC to β-carbolines and their application for the β-carboline alkaloids synthesis

S Gaikwad, L Kováčiková, P Pawar, M Gaikwad… - Tetrahedron, 2024 - Elsevier
This review is an informative and constructive resource for researchers interested in the
synthesis of β-carbolines. It provides a comprehensive overview of the various synthetic …

Benzannulation strategies for the synthesis of carbazoles, indolocarbazoles, benzocarbazoles, and carbolines

A Banerjee, S Kundu, A Bhattacharyya… - Organic Chemistry …, 2021 - pubs.rsc.org
Nitrogen-containing π-excessive aromatic heterocycles, in particular, carbazoles,
indolocarbazoles, benzocarbazoles, and carbolines have been considered the fundamental …

Synthesis and cytotoxic activities of β-carboline amino acid ester conjugates

M Zhao, L Bi, W Wang, C Wang, M Baudy-Floc'h… - Bioorganic & medicinal …, 2006 - Elsevier
β-Carboline represents a class of compounds with potent anti-tumor activity by intercalating
with DNA. To further enhance the cytotoxic potency and bioavailability of β-carboline, a …