Molecular mechanisms of human papillomavirus-induced carcinogenesis

M Lehoux, CM D'Abramo, J Archambault - Public health genomics, 2009 - karger.com
Approximately 20% of all cancers are associated with infectious agents. Among them,
human papillomaviruses (HPVs) are very common and are now recognized as the …

Molecular signature of HPV-induced carcinogenesis: pRb, p53 and gene expression profiling

Á Buitrago-Pérez, G Garaulet… - Current …, 2009 - ingentaconnect.com
The infection by mucosal human papillomavirus (HPV) is causally associated with tumor
development in cervix and oropharynx. The mechanisms responsible for this oncogenic …

The molecular mechanism of human papillomavirus-induced carcinogenesis in head and neck squamous cell carcinoma

D Sano, N Oridate - International journal of clinical oncology, 2016 - Springer
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer
worldwide. Recently, the incidence of oropharyngeal cancer (OPC) has increased markedly …

Understanding the HPV integration and its progression to cervical cancer

MA Oyervides-Muñoz, AA Pérez-Maya… - Infection, Genetics and …, 2018 - Elsevier
Cervical cancer is one of the main causes of female cancer death worldwide, and human
papilloma virus (HPV) its causal agent. To investigate viral oncogenesis several studies …

Long-read sequencing reveals oncogenic mechanism of HPV-human fusion transcripts in cervical cancer

M Liu, Z Han, Y Zhi, Y Ruan, G Cao, G Wang, X Xu… - Translational …, 2023 - Elsevier
Integration of high-risk human papillomavirus (HPV) into the host genome is a crucial event
for the development of cervical cancer, however, the underlying mechanism of HPV …

Human papillomaviruses and associated malignancies.

RM Alani, K Münger - Journal of clinical oncology, 1998 - ascopubs.org
The human papillomaviruses (HPVS) are small DNA tumor viruses that infect epithelial cells
and induce proliferative lesions. Substantial epidemiologic data along with in vitro and in …

Biology of HPV mediated carcinogenesis and tumor progression

PF Cosper, S Bradley, Q Luo, RJ Kimple - Seminars in radiation oncology, 2021 - Elsevier
Human papillomavirus (HPV) is a ubiquitous DNA virus that infects squamous epithelia.
Though HPV only encodes 8 genes, it is capable of causing cellular transformation and …

Molecular analyses and prognostic relevance of HPV in head and neck tumours

G Badaracco, C Rizzo, B Mafera, B Pichi… - Oncology …, 2007 - spandidos-publications.com
HPV involvement in head and neck (HN) cancer is still under active investigation. Fresh
frozen and archival clinical samples from 115 patients affected by HN carcinomas were …

Human papillomavirus drives tumor development throughout the head and neck: improved prognosis is associated with an immune response largely restricted to the …

A Chakravarthy, S Henderson… - Journal of Clinical …, 2016 - ascopubs.org
Purpose In squamous cell carcinomas of the head and neck (HNSCC), the increasing
incidence of oropharyngeal squamous cell carcinomas (OPSCCs) is attributable to human …

Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism

Z Hu, D Zhu, W Wang, W Li, W Jia, X Zeng, W Ding… - Nature …, 2015 - nature.com
Human papillomavirus (HPV) integration is a key genetic event in cervical carcinogenesis.
By conducting whole-genome sequencing and high-throughput viral integration detection …