Male infertility is a heterogeneous condition of largely unknown etiology that affects at least
7% of men worldwide. Classical genetic approaches and emerging next-generation …

Early in embryogenesis, cells that are destined to become germ cells take on a different
destiny from other cells in the embryo. The germ cells are not programmed to perform “vital” …

Male infertility is a common and complex disease, manifesting as a wide range of
phenotypes, ranging from apparently normal semen parameters with an inexplicable …

BACKGROUND Functional male gametes are produced through complex processes that
take place within the testis, epididymis and female reproductive tract. A breakdown at any of …

Approximately 80 million people worldwide are infertile, and nearly half of all infertility cases
are attributed to a male factor. Therefore, progress in reproductive genetics becomes crucial …

Male infertility is a multifactorial complex disease with highly heterogeneous phenotypic
representation and in at least 15% of cases, this condition is related to known genetic …

Limited knowledge of the genetic causes of male infertility has resulted in few treatment and
targeted therapeutic options. Although the ideal approach to identify infertility causing …

The complexity of male reproductive impairment has hampered characterization of the
underlying genetic causes of male infertility. However, in the last 20 years, more powerful …

A thorough understanding of the genetic basis of male infertility has eluded researchers in
spite of significant efforts to identify novel genetic causes of the disease, particularly over the …

Many advances have been recently made in understanding the genetic control of fertility in
model systems. This review concentrates on genetic causes of male factor infertility in …