Dextran-based biodegradable nanoparticles: an alternative and convenient strategy for treatment of traumatic spinal cord injury

W Liu, P Quan, Q Li, P Tang, J Chen… - International journal of …, 2018 - Taylor & Francis
Introduction After traumatic spinal cord injury (SCI), an inhibitory environment that contains
chondroitin sulfate proteoglycans (CSPGs) is formed that prevents axonal regeneration and …

Paclitaxel-incorporated nanoparticles improve functional recovery after spinal cord injury

X Zhang, W Xiong, G Kong, Y Zhen, Q Zeng… - Frontiers in …, 2022 - frontiersin.org
As a worldwide medical problem, spinal cord injury has no clear and effective treatment to
improve its prognosis. Hence, new treatment strategies for spinal cord injury with good …

Local delivery of chondroitinase ABC with or without stromal cell-derived factor 1α promotes functional repair in the injured rat spinal cord

MM Pakulska, CH Tator, MS Shoichet - Biomaterials, 2017 - Elsevier
Traumatic spinal cord injury (SCI) is a devastating event for which functional recovery
remains elusive. Due to the complex nature of SCI pathology, a combination treatment …

Nanoparticle technologies in the spinal cord

JM Zuidema, RJ Gilbert, DJ Osterhout - Cells Tissues Organs, 2016 - karger.com
Nanoparticles are increasingly being studied within experimental models of spinal cord
injury (SCI). They are used to image cells and tissue, move cells to specific regions of the …

Locally controlled release of immunosuppressive promotes survival of transplanted adult spinal cord tissue

Z Wang, Y Li, C Sun, P Cui, Y Han, T Wu… - Regenerative …, 2023 - academic.oup.com
Transplantation of adult spinal cord tissue (aSCT) is a promising treatment for spinal cord
injury (SCI) basing on various types of neural cells and matrix components inside aSCT …

Controlled release of chondroitinase ABC in chitosan-based scaffolds and PDLLA microspheres

YC Huang, SH Hsu, MT Chen, CH Hsieh, WC Kuo… - Carbohydrate …, 2011 - Elsevier
Spinal cord injury (SCI) can trigger inhibitory signal cascades that promote the expression of
chondroitin sulfate proteoglycans (CSPGs), which are the main structures in scar tissue. The …

NSCs migration promoted and drug delivered exosomes‐collagen scaffold via a bio‐specific peptide for one‐step spinal cord injury repair

L Zhang, C Fan, W Hao, Y Zhuang, X Liu… - Advanced …, 2021 - Wiley Online Library
Spinal cord injury (SCI) is plaguing medical professionals globally due to the complexity of
injury progression. Based on tissue engineering technology, there recently emerges a …

Biodegradable spheres protect traumatically injured spinal cord by alleviating the glutamate‐induced Excitotoxicity

D Liu, J Chen, T Jiang, W Li, Y Huang, X Lu… - Advanced …, 2018 - Wiley Online Library
New treatment strategies for spinal cord injury with good therapeutic efficacy are actively
pursued. Here, acetalated dextran (AcDX), a biodegradable polymer obtained by modifying …

Diacerein loaded poly (styrene sulfonate) and carbon nanotubes injectable hydrogel: an effective therapy for spinal cord injury regeneration

S Xing, M Yan, Y Yang, Y Wang, X Hu, B Ma… - Journal of Cluster …, 2023 - Springer
Good structural features with good conduction to transfer the electrical signal in the spinal
cord are perilous in nerve soft tissue repairing materials preparation. In this research work …

A novel hydrogel-based combination therapy for effective neuroregeneration after spinal cord injury

Q Wang, X Dong, H Zhang, P Li, X Lu, M Wu… - Chemical Engineering …, 2021 - Elsevier
Spinal cord injury (SCI) remains a challenging clinical problem worldwide. Combination
therapy is a promising therapeutic strategy for SCI. Recent investigations have reported that …