Notch signalling in healthy and diseased vasculature

F Del Gaudio, D Liu, U Lendahl - Open Biology, 2022 - royalsocietypublishing.org
Notch signalling is an evolutionarily highly conserved signalling mechanism governing
differentiation and regulating homeostasis in many tissues. In this review, we discuss recent …

Role of Notch in endothelial biology

M Fernández-Chacón, I García-González, S Mühleder… - Angiogenesis, 2021 - Springer
The Notch signalling pathway is one of the main regulators of endothelial biology. In the last
20 years the critical function of Notch has been uncovered in the context of angiogenesis …

Notch signaling in vascular development and physiology

T Gridley - 2007 - journals.biologists.com
Notch signaling is an ancient intercellular signaling mechanism that plays myriad roles
during vascular development and physiology in vertebrates. These roles include regulation …

Notch signaling in blood vessels: who is talking to whom about what?

JJ Hofmann, ML Iruela-Arispe - Circulation research, 2007 - Am Heart Assoc
It has become increasingly clear that the Notch signaling pathway plays a critical role in the
development and homeostasis of the cardiovascular system. This notion has emerged from …

Notch signal integration in the vasculature during remodeling

B Rostama, SM Peterson, CPH Vary, L Liaw - Vascular pharmacology, 2014 - Elsevier
Notch signaling plays many important roles in homeostasis and remodeling in the vessel
wall, and serves a critical role in the communication between endothelial cells and smooth …

Impact of notch signaling on inflammatory responses in cardiovascular disorders

T Quillard, B Charreau - International journal of molecular sciences, 2013 - mdpi.com
Notch signaling is a major pathway in cell fate decisions. Since the first reports showing the
major role of Notch in embryonic development, a considerable and still growing literature …

Notch signaling in endothelial cells: is it the therapeutic target for vascular neointimal hyperplasia?

DY Tian, XR Jin, X Zeng, Y Wang - International journal of molecular …, 2017 - mdpi.com
Blood vessels respond to injury through a healing process that includes neointimal
hyperplasia. The vascular endothelium is a monolayer of cells that separates the outer …

Notch signaling in vascular morphogenesis

JA Alva, ML Iruela-Arispe - Current opinion in hematology, 2004 - journals.lww.com
An emerging hallmark of the Notch signaling pathway is its nearly ubiquitous participation in
cell fate decisions that affect several tissues, including epithelial, neuronal, hematopoietic …

Notch function in the vasculature: insights from zebrafish, mouse and man

CJ Shawber, J Kitajewski - Bioessays, 2004 - Wiley Online Library
Vascular development entails multiple cell‐fate decisions to specify a diverse array of
vascular structures. Notch proteins are signaling receptors that regulate cell‐fate …

Notch signaling in the vasculature

T Gridley - Current topics in developmental biology, 2010 - Elsevier
Notch signaling is an evolutionarily conserved, intercellular signaling mechanism that plays
myriad roles during vascular development and physiology in vertebrates. These roles …