Minocycline attenuates pain by inhibiting spinal microglia activation in diabetic rats
JS Sun, YJ Yang, YZ Zhang… - Molecular …, 2015 - spandidos-publications.com
The mechanisms associated with diabetes-induced neuropathic pain are complex and
poorly understood. In order to understand the involvement of spinal microglia activity in …
poorly understood. In order to understand the involvement of spinal microglia activity in …
Minocycline reduces mechanical allodynia and depressive-like behaviour in type-1 diabetes mellitus in the rat
D Amorim, S Puga, R Braganca, A Braga… - Behavioural brain …, 2017 - Elsevier
A common and devastating complication of diabetes mellitus is painful diabetic neuropathy
(PDN) that can be accompanied by emotional disorders such as depression. A few studies …
(PDN) that can be accompanied by emotional disorders such as depression. A few studies …
Minocycline completely reverses mechanical hyperalgesia in diabetic rats through microglia‐induced changes in the expression of the potassium chloride co …
C Morgado, P Pereira‐Terra, CD Cruz… - Diabetes, Obesity and …, 2011 - Wiley Online Library
Aim: Neuronal hyperactivity at the spinal cord during mechanical hyperalgesia induced by
diabetes may result from a decrease in the local expression of the potassium chloride co …
diabetes may result from a decrease in the local expression of the potassium chloride co …
Minocycline attenuates the development of diabetic neuropathic pain: possible anti-inflammatory and anti-oxidant mechanisms
Painful neuropathy, a common complication of diabetes mellitus is characterized by
allodynia and hyperalgesia. Recent studies emphasized on the role of non-neuronal cells …
allodynia and hyperalgesia. Recent studies emphasized on the role of non-neuronal cells …
Minocycline influences the anti-inflammatory interleukins and enhances the effectiveness of morphine under mice diabetic neuropathy
M Zychowska, E Rojewska, G Kreiner, I Nalepa… - Journal of …, 2013 - Elsevier
A single streptozotocin (STZ) injection in mice can induce significant neuropathic pain along
with an increase in plasma glucose levels and a decrease in body weight. Seven days after …
with an increase in plasma glucose levels and a decrease in body weight. Seven days after …
Ammoxetine attenuates diabetic neuropathic pain through inhibiting microglial activation and neuroinflammation in the spinal cord
TT Zhang, R Xue, SY Fan, QY Fan, L An, J Li… - Journal of …, 2018 - Springer
Background Diabetic neuropathic pain (DNP) is a common and distressing complication in
patients with diabetes, and the underlying mechanism remains unclear. Tricyclic …
patients with diabetes, and the underlying mechanism remains unclear. Tricyclic …
Minocycline attenuates the development of diabetic neuropathy by inhibiting spinal cord Notch signaling in rat
C Yang, J Gao, B Wu, N Yan, H Li, Y Ren, Y Kan… - Biomedicine & …, 2017 - Elsevier
We studied the effects of minocycline (an inhibitor of microglial activation) on the expression
and activity of Notch-1 receptor, and explored the therapeutic efficacy of minocycline …
and activity of Notch-1 receptor, and explored the therapeutic efficacy of minocycline …
Pyridoxamine alleviates mechanical allodynia by suppressing the spinal receptor for advanced glycation end product-nuclear factor-κ B/extracellular signal-regulated …
X Zhang, L Xu, W Chen, X Yu, L Shen… - Molecular …, 2020 - journals.sagepub.com
Diabetic neuropathic pain is a common complication of diabetes mellitus and requires a
substantial amount of societal resources. Pyridoxamine is an inhibitor of advanced glycation …
substantial amount of societal resources. Pyridoxamine is an inhibitor of advanced glycation …
[HTML][HTML] Novel mechanism for memantine in attenuating diabetic neuropathic pain in mice via downregulating the spinal HMGB1/TRL4/NF-kB inflammatory axis
Diabetic neuropathic pain (DNP) is a common diabetic complication that currently lacks an
efficient therapy. The aim of the current work was to uncover the anti-allodynic and …
efficient therapy. The aim of the current work was to uncover the anti-allodynic and …
Spinal astrocytic activation contributes to mechanical allodynia in a mouse model of type 2 diabetes
YH Liao, GH Zhang, D Jia, P Wang, NS Qian, F He… - Brain research, 2011 - Elsevier
Diabetic neuropathic pain (DNP) plays a major role in decreased life quality of type 2
diabetes patients, however, the molecular mechanisms underlying DNP remain unclear …
diabetes patients, however, the molecular mechanisms underlying DNP remain unclear …