The mechanisms associated with diabetes-induced neuropathic pain are complex and
poorly understood. In order to understand the involvement of spinal microglia activity in …

A common and devastating complication of diabetes mellitus is painful diabetic neuropathy
(PDN) that can be accompanied by emotional disorders such as depression. A few studies …

Aim: Neuronal hyperactivity at the spinal cord during mechanical hyperalgesia induced by
diabetes may result from a decrease in the local expression of the potassium chloride co …

Painful neuropathy, a common complication of diabetes mellitus is characterized by
allodynia and hyperalgesia. Recent studies emphasized on the role of non-neuronal cells …

A single streptozotocin (STZ) injection in mice can induce significant neuropathic pain along
with an increase in plasma glucose levels and a decrease in body weight. Seven days after …

Background Diabetic neuropathic pain (DNP) is a common and distressing complication in
patients with diabetes, and the underlying mechanism remains unclear. Tricyclic …

We studied the effects of minocycline (an inhibitor of microglial activation) on the expression
and activity of Notch-1 receptor, and explored the therapeutic efficacy of minocycline …

Diabetic neuropathic pain is a common complication of diabetes mellitus and requires a
substantial amount of societal resources. Pyridoxamine is an inhibitor of advanced glycation …

Diabetic neuropathic pain (DNP) is a common diabetic complication that currently lacks an
efficient therapy. The aim of the current work was to uncover the anti-allodynic and …

Diabetic neuropathic pain (DNP) plays a major role in decreased life quality of type 2
diabetes patients, however, the molecular mechanisms underlying DNP remain unclear …