GPCRs (G-protein-coupled receptors) are among the most important targets for drug
discovery due to their ubiquitous expression and participation in cellular events under both …

Over 80 years has passed since the discovery of substance P (SP), and a variety of peptides
of the tachykinin (TK) family have been found and investigated. SP, neurokinin A (NKA), and …

The aim of this article is to furnish a brief review of the role played by neurokinins in the
inflammatory process. Further attention is given to the mechanisms, as well as to the …

Recently, the cloning of a novel preprotachykinin gene (PPT-C) has been reported. This
gene codes for a novel peptide named hemokinin 1 (HK-1). In contrast with the known …

Evidence has been mounting for peripheral functions for tachykinins, a family of
neuropeptides including substance P (SP), neurokinin A, and neurokinin B, which are …

Growing evidence points to the existence of the components of the kallikrein-kinin-system
(KKS) in cardiac and vascular tissue forming systemic and local KKS pathways involving …

The tachykinin peptide family certainly represents one of the largest peptide families
described in the animal organism. So far, more than 40 tachykinins have been isolated from …

Kinins are autacoid peptides and central neuromediators involved in cardiovascular
regulation, inflammation and pain. Their effects are mediated by two transmembrane G …

Neurokinins (mainly substance P and neurokinin A) are released by sensitive nerve fibres.
These fibres have been found in the vascular wall of arteries and veins of many vascular …

Substance P as a member of tachykinin family plays an important role in angiogenesis.
Hemokinins (HKs) have been identified as new members of substance P-like peptides of …