Vascular targeting of nanocarriers: perplexing aspects of the seemingly straightforward paradigm

M Howard, BJ Zern, AC Anselmo, VV Shuvaev… - ACS …, 2014 - ACS Publications
Targeted nanomedicine holds promise to find clinical use in many medical areas.
Endothelial cells that line the luminal surface of blood vessels represent a key target for …

Non-affinity factors modulating vascular targeting of nano-and microcarriers

JW Myerson, AC Anselmo, Y Liu, S Mitragotri… - Advanced drug delivery …, 2016 - Elsevier
Particles capable of homing and adhering to specific vascular biomarkers have potential as
fundamental tools in drug delivery for mediation of a wide variety of pathologies, including …

Targeted endothelial nanomedicine for common acute pathological conditions

VV Shuvaev, JS Brenner, VR Muzykantov - Journal of Controlled Release, 2015 - Elsevier
Endothelium, a thin monolayer of specialized cells lining the lumen of blood vessels is the
key regulatory interface between blood and tissues. Endothelial abnormalities are …

Targeting drug delivery in the vascular system: Focus on endothelium

PM Glassman, JW Myerson, LT Ferguson… - Advanced drug delivery …, 2020 - Elsevier
The bloodstream is the main transporting pathway for drug delivery systems (DDS) from the
site of administration to the intended site of action. In many cases, components of the …

Vascular‐targeted nanocarriers: design considerations and strategies for successful treatment of atherosclerosis and other vascular diseases

WJ Kelley, H Safari, G Lopez‐Cazares… - Wiley …, 2016 - Wiley Online Library
Vascular‐targeted nanocarriers are an attractive option for the treatment of a number of
cardiovascular diseases, as they allow for more specific delivery and increased efficacy of …

Computational model for nanocarrier binding to endothelium validated using in vivo, in vitro, and atomic force microscopy experiments

J Liu, GER Weller, B Zern… - Proceedings of the …, 2010 - National Acad Sciences
A computational methodology based on Metropolis Monte Carlo (MC) and the weighted
histogram analysis method (WHAM) has been developed to calculate the absolute binding …

Nanomedicine approaches in vascular disease: a review

AS Gupta - Nanomedicine: Nanotechnology, Biology and Medicine, 2011 - Elsevier
Nanomedicine approaches have revolutionized the treatment of cancer and vascular
diseases, where the limitations of rapid nonspecific clearance, poor biodistribution and …

Vascular targeting of nanoparticles for molecular imaging of diseased endothelium

PU Atukorale, G Covarrubias, L Bauer… - Advanced drug delivery …, 2017 - Elsevier
This review seeks to highlight the enormous potential of targeted nanoparticles for molecular
imaging applications. Being the closest point-of-contact, circulating nanoparticles can gain …

Dynamic and cellular interactions of nanoparticles in vascular-targeted drug delivery

RB Huang, S Mocherla, MJ Heslinga… - Molecular membrane …, 2010 - Taylor & Francis
Vascular-targeted drug delivery systems could provide more efficient and effective
pharmaceutical interventions for treating a variety of diseases including cardiovascular …

Advances in the treatment of atherosclerosis with ligand‐modified nanocarriers

X Deng, J Wang, S Yu, S Tan, T Yu, Q Xu, N Chen… - …, 2024 - Wiley Online Library
Atherosclerosis, a chronic disease associated with metabolism, poses a significant risk to
human well‐being. Currently, existing treatments for atherosclerosis lack sufficient efficiency …