Objective: The resolution of neutrophil (PMN)-mediated inflammation occurs through the
apoptosis, or programmed cell death, of the neutrophil. PMN apoptosis is inhibited by a …

Delayed neutrophil apoptosis and overshooting neutrophil activity contribute to organ
dysfunction and subsequent organ failure in sepsis. Here, we investigated apoptotic …

Sepsis is a prevalent disease that has alarmingly high mortality rates and, for several
survivors, long-term morbidity. The modern definition of sepsis is an aberrant host response …

Neutrophils play a key role in the pathophysiology of septic multiple organ dysfunction
syndrome (MODS) through excessive release of toxic granule components and reactive …

PURPOSE: The aims were to analyze the temporal evolution of neutrophil apoptosis, to
determine the differences in neutrophil apoptosis among 28-day survivors and nonsurvivors …

Neutrophil is a major player in the pathophysiology of severe sepsis. Recent studies have
revealed that the cell death mechanism of neutrophils directly relates to the development of …

Neutrophil constitutive death is a critical cellular process for modulating neutrophil number
and function, and it plays an essential role in neutrophil homeostasis and the resolution of …

We evaluated neutrophil activation by measuring its phagocytic ability and oxidative burst
activity in 16 patients with sepsis and 16 healthy volunteers. We also focused on neutrophil …

Patients with sepsis are immune compromised, as evidenced by their failure to clear their
primary infection and their propensity to develop secondary infections with pathogens that …

Background. Prolonged polymorphonuclear neutrophil (PMN) survival has been implicated
in tissue injury after sepsis. Previously we reported that lipopolysaccharide (LPS) inhibits …