Intrauterine infection and inflammation are major reasons for preterm birth. The switch from
placenta-mediated to lung-mediated oxygen supply during birth is associated with a sudden …

The mechanisms of injury-and disease-related degeneration of motor neurons (MNs) need
clarification. Unilateral avulsion of the sciatic nerve in the mouse induces apoptosis of spinal …

Neuronal nitric oxide synthase (nNOS) and nitric oxide (NO) are implicated in neuronal
injury following acute hypoxia-ischemia (HI). Our hypothesis was that NO from nNOS is …

Background Inflammation-activated glia are seen in many CNS pathologies and may kill
neurons through the release of cytotoxic mediators, such as nitric oxide from inducible NO …

We have investigated the mechanism of nitric oxide-induced damage in glial cells. Genomic
DNA isolated from astrocytes and microglia, treated for 18 h with varying concentrations of a …

Inflammatory‐activated glia are seen in numerous central nervous system (CNS)
pathologies and can kill nearby neurons through the release of cytotoxic mediators. Glia …

Oxygen free radicals and nitric oxide (NO) participate in the pathogenesis of acute central
nervous system (CNS) injury by forming peroxynitrite, which promotes oxidative damage …

Dementia in Alzheimer's disease (AD) is correlated with cell loss that is mediated by
apoptosis, mitochondrial (Mt) dysfunction, and possibly necrosis. Previous studies …

The activation of the nuclear receptor peroxisome proliferator-activated receptor-γ (PPAR-γ)
is known to exert anti-inflammatory and neuroprotective effects and PPAR-γ agonists are …

Periventricular leukomalacia (PVL), the main substrate for cerebral palsy, is characterized by
diffuse injury of deep cerebral white matter, accompanied in its most severe form by focal …