Myelination is a complex and orderly process during brain development that is essential for
normal motor, cognitive and sensory functions. Cellular and molecular interactions between …

Neonatal hypoxia-ischemia in the preterm human leads to selective injury to the subcortical
developing white matter, which results in periventricular leukomalacia (PVL), a condition …

Oxidative damage is a common and early feature of Alzheimer's disease, Parkinson's
disease, amyotrophic lateral sclerosis (ALS), and other neurodegenerative disorders. Dr …

Nitric oxide has been implicated in the pathogenesis of multiple sclerosis. However, it is still
unclear whether nitric oxide plays a protective role or is deleterious. We have previously …

Background Several clinical conditions are associated with white matter injury, including
periventricular white matter injury (PWMI), which is a form of brain injury sustained by …

One-week-old rat pups were subjected to an acute 10 min severe hypoxic–ischemic insult.
Over the next 24 h, during the reperfusion period, O4 immunocytochemistry demonstrated …

Depending on its concentration, nitric oxide (NO) has beneficial or toxic effects. In
pathological conditions, NO reacts with superoxide to form peroxynitrite, which nitrates …

Aims: Periventricular white matter injury in premature infants occurs following
hypoxia/ischaemia and systemic infection, and results in hypomyelination, as well as …

Hypoxic exposure in the perinatal period causes periventricular white matter damage
(PWMD), a condition associated with myelination abnormalities. Under hypoxic conditions …

Hypoxia/ischaemia is known to trigger neuronal death, but the role of neuronal nitric oxide
synthase (nNOS) in this process is controversial. Nitric oxide (NO) inhibits cytochrome …