We reported previously that low levels of nitric oxide (NO) induced cell death with properties
of apoptosis, including chromatin fragmentation and condensation in undifferentiated PC12 …

Poor neurological outcome in preterm infants is associated with periventricular white matter
damage and hypomyelination, often caused by perinatal inflammation, hypoxia–ischemia …

BACKGROUND: Inflammation and reactive oxygen species (ROS) are important in the
development of perinatal brain injury. The ROS-generating enzyme NADPH oxidase (Nox2) …

There is mounting evidence that nitric oxide (NO) is produced in the brains of patients with
multiple sclerosis (MS) and in the experimental model of MS, experimental autoimmune …

Periventricular leukomalacia (PVL) is a common ischemic brain injury in premature infants
for which there is no effective treatment. The objective of this study was to determine whether …

With significant improvements in neonatal care, fewer infants sustain severe injury as a
consequence of hypoxia/ischemia (H/I). However, the majority of experimental studies have …

Cortical nitric oxide (NO) production increases during hypoxia/ischemia in the immature
brain and is associated with both neurotoxicity and mitochondrial dysfunction. Mitochondrial …

Perinatal brain injury in survivors of premature birth has a unique and unexplained
predilection for periventricular cerebral white matter. Periventricular white‐matter injury …

We hypothesized that elimination of neuronal nitric oxide synthase (nNOS) by targeted
disruption of the nNOS gene would result in amelioration of damage seen after hypoxia …

Astrocytes may modulate the survival of motor neurons in amyotrophic lateral sclerosis
(ALS). We have previously shown that fibroblast growth factor‐1 (FGF‐1) activates …