Peptides are privileged ligands for diverse biomacromolecules, including proteins; however,
their utility is often limited due to low membrane permeability and in-cell instability. Here, we …

The spatial alignment of functional groups is a central aspect of most catalytic processes.
Protein scaffolds with their exceptional molecular recognition properties have evolved into …

Chemical modification of proteins provides powerful tools to realize a broad range of
exciting biological applications, including the development of new classes of …

In contrast to large proteins, small peptide catalysts typically display limited specificity for
small molecule substrates. This is presumably a result of the limited opportunities small …

Ligand-directed reactions allow chemical transformations at very low reactant
concentrations and can thus provide access to efficient approaches for the post-translational …

Protein synthesis and semisynthesis offer immense promise for life sciences and have
impacted pharmaceutical innovation. The absence of a generally applicable method for …

Recently a number of nonnatural prenyl groups containing alkynes and azides have been
developed as handles to perform click chemistry on proteins and peptides ending in the …

In the past decade, numerous chemical technologies have been developed to allow the site-
specific post-translational modification of proteins. Traditionally covalent chemical protein …

The rising demand for regioselective protein modifications in chemical biology and
pharmaceutical manufacturing has fueled efforts to develop diverse techniques that …

Peptide modulators targeting protein–protein interactions (PPIs) exhibit greater potential
than small-molecule drugs in several important aspects including facile modification and …