Human p14ARF-mediated cell cycle arrest strictly depends on intact p53 signaling pathways
HO Weber, T Samuel, P Rauch, JO Funk - Oncogene, 2002 - nature.com
The tumor suppressor ARF is transcribed from the INK4a/ARF locus in partly overlapping
reading frames with the CDK inhibitor p16 Ink4a. ARF is able to antagonize the MDM2 …
reading frames with the CDK inhibitor p16 Ink4a. ARF is able to antagonize the MDM2 …
p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice
B Eymin, C Leduc, JL Coll, E Brambilla, S Gazzeri - Oncogene, 2003 - nature.com
Until recently, the ability of ARF (human p14 ARF, murine p19 ARF) tumour-suppressor
protein, encoded by the INK4A/ARF locus, to inhibit cell growth in response to various stimuli …
protein, encoded by the INK4A/ARF locus, to inhibit cell growth in response to various stimuli …
Loss of p21 disrupts p14ARF-induced G1 cell cycle arrest but augments p14ARF-induced apoptosis in human carcinoma cells
PG Hemmati, G Normand, B Verdoodt, C von Haefen… - Oncogene, 2005 - nature.com
The human INK4a locus encodes two structurally unrelated tumor suppressor proteins, p16
INK4a and p14 ARF (p19 ARF in the mouse), which are frequently inactivated in human …
INK4a and p14 ARF (p19 ARF in the mouse), which are frequently inactivated in human …
p19ARF prevents G1 cyclin-dependent kinase activation by interacting with MDM2 and activating p53 in mouse fibroblasts
K Kurokawa, T Tanaka, J Kato - Oncogene, 1999 - nature.com
Abstract p19 ARF encoded by the INK4a tumor suppressor gene locus functions upstream of
p53 to induce cell cycle arrest. p19 ARF can interact with MDM2 and p53 in cells ectopically …
p53 to induce cell cycle arrest. p19 ARF can interact with MDM2 and p53 in cells ectopically …
Adenovirus-mediated overexpression of p14ARF induces p53 and Bax-independent apoptosis
PG Hemmati, B Gillissen, C von Haefen, J Wendt… - Oncogene, 2002 - nature.com
The human INK4a gene locus encodes two structurally unrelated tumor suppressor proteins,
p16 INK4a and p14 ARF, which are frequently inactivated in human cancer. Whereas p16 …
p16 INK4a and p14 ARF, which are frequently inactivated in human cancer. Whereas p16 …
Cooperative effect of p21Cip1/WAF− 1 and 14-3-3σ on cell cycle arrest and apoptosis induction by p14ARF
PG Hemmati, G Normand, B Gillissen, J Wendt… - Oncogene, 2008 - nature.com
Abstract P14 ARF (p19 ARF in the mouse) plays a central role in the regulation of cellular
proliferation. Although the capacity of p14 ARF to induce a cell cycle arrest in G1 phase …
proliferation. Although the capacity of p14 ARF to induce a cell cycle arrest in G1 phase …
p14ARF induces G2 cell cycle arrest in p53-and p21-deficient cells by down-regulating p34cdc2 kinase activity
G Normand, PG Hemmati, B Verdoodt… - Journal of Biological …, 2005 - ASBMB
The human INK4a gene locus encodes two structurally unrelated tumor suppressor proteins,
p16 INK4a and p14 ARF. Although primarily proposed to require a functional p53· Mdm-2 …
p16 INK4a and p14 ARF. Although primarily proposed to require a functional p53· Mdm-2 …
Arf induces p53-dependent and-independent antiproliferative genes
ML Kuo, EJ Duncavage, R Mathew, W Den Besten… - Cancer Research, 2003 - AACR
The tumor suppressor p19Arf (p14ARF in humans), encoded by the Ink4a/Arf locus, is
mutated, deleted, or silenced in many forms of cancer. p19Arf induces growth arrest by …
mutated, deleted, or silenced in many forms of cancer. p19Arf induces growth arrest by …
ATM activity contributes to the tumor-suppressing functions of p14ARF
Abstract P14/p19 ARF (ARF) plays a major role in the activation of p53 by oncogenic
signals. The biochemical basis of this has not been fully elucidated. We report here that …
signals. The biochemical basis of this has not been fully elucidated. We report here that …
p14ARF regulates E2F-1 ubiquitination and degradation via a p53-dependent mechanism
H Rizos, LL Scurr, M Irvine, NJ Alling, RF Kefford - Cell Cycle, 2007 - Taylor & Francis
Alterations in the ARF tumour suppressor protein (also known as p14ARF in humans and
p19ARF in the mouse) occur frequently in cancer and are associated with susceptibility to …
p19ARF in the mouse) occur frequently in cancer and are associated with susceptibility to …