Combined immunodeficiencies with impaired numbers and function of T-and B-cells can be
attributed to defects in the recombinase activating genes (RAG). The products of these …

Mutations in the recombination activating genes (RAG1 or RAG2) can lead to a variety of
immunodeficiencies. Herein, we report 5 cases of RAG deficiency from 5 families: 3 of …

Background V (D) J recombination takes place during lymphocyte development to generate
a large repertoire of T-and B-cell receptors. Mutations in recombination-activating gene 1 …

Background The recombination-activating gene (RAG) 1/2 proteins play a critical role in the
development of T and B cells by initiating the VDJ recombination process that leads to …

Background Severe combined immunodeficiency is within a heterogeneous group of
inherited defects throughout the development of T-and/or B-lymphocytes. Mutations in …

We report different immunological phenotypes in three siblings from consanguineous family
with recombinase‐activating gene 1 (RAG1) gene mutations. Null mutations of RAG genes …

Mutations in recombination activating genes 1 and 2 (RAG1 and RAG2) cause a spectrum of
severe immunodeficiencies ranging from classical T cell–B cell–severe combined …

Severe combined immunodeficiency (SCID) comprises a heterogeneous group of primary
immunodeficiencies, a proportion of which are due to mutations in either of the 2 …

Mutations of the recombinase activating genes (RAG) in humans underlie a broad spectrum
of clinical and immunological phenotypes that reflect different degrees of impairment of T …

Abstract Recombination-activating genes (RAG) 1 and RAG2 initiate the molecular
processes that lead to lymphocyte receptor formation through VDJ recombination. Nonsense …