Over the past 20 years, the concept of mammalian autophagy as a nonselective degradation
system has been repudiated, due in part to important discoveries in neurodegenerative …

Selective autophagy of mitochondria, or mitophagy, refers to the specific removal and
degradation of damaged or surplus mitochondria via targeting to the lysosome for …

The quality of mitochondria, essential organelles that produce ATP and regulate numerous
metabolic pathways, must be strictly monitored to maintain cell homeostasis. The loss of …

Autophagy is the process by which cells can selectively or non-selectively remove damaged
proteins and organelles. As the cell's main means of sequestering damaged mitochondria …

Mitochondria produce energy in the form of ATP via oxidative phosphorylation. As defects in
oxidative phosphorylation can generate harmful reactive oxygen species, it is important that …

Macroautophagy is a cellular process by which cytosolic components and organelles are
degraded in double-membrane bound structures upon fusion with lysosomes. A pathway for …

Mitochondria are multifunctional subcellular organelles essential for cellular energy
homeostasis and apoptotic cell death. It is, therefore, crucial to maintain mitochondrial …

Mitochondria-specific autophagy (mitophagy) is a fundamental process critical for
maintaining mitochondrial fitness in a myriad of cell types. Particularly, mitophagy …

As a central hub for cellular metabolism and intracellular signaling, the mitochondrion is a
pivotal organelle, dysfunction of which has been linked to several human diseases including …

Functional mitochondria are critically important for the maintenance of cellular integrity and
survival. Mitochondrial dysfunction is a major contributor to neurodegenerative diseases …