With the introduction of precision genome editing using CRISPR–Cas9 technology, we have
entered a new era of genetic engineering and gene therapy. With RNA-guided …

Scaffold-assisted gene therapy is a highly promising tool to treat articular cartilage lesions
upon direct delivery of chondrogenic candidate sequences. The goal of this study was to …

CRISPR-Cas9 genome editing is a promising technique for clinical applications, such as the
correction of disease-associated alleles in somatic cells. The use of this approach has also …

The CRISPR/Cas9 system has emerged as a powerful tool for mammalian genome
engineering. In basic and translational intervertebral disc (IVD) research, this technique has …

© The American Society of Gene & Cell Therapy commentary dality. Both AAV8 and AAV9
mediate efficient gene transfer in skeletal muscle and heart22–24 after systemic …

The ability to efficiently and reproducibly edit genomes using engineered nucleases is one
of the major biological advances of the past few decades and is generating considerable …

Recently, the CRISPR/Cas9 system is emerging as a powerful tool for genome editing
(Chang et al., 2013; Li et al., 2013; Niu et al., 2014; Shen et al., 2013; Wan et al., 2015; …

The application of chondrogenic gene sequences to human bone marrow-derived
mesenchymal stromal cells (hMSCs) is an attractive strategy to activate the reparative …

The recently developed CRISPR/Cas9 technology has revolutionized the genome
engineering field. Since 2016, increasing number of studies regarding CRISPR therapeutics …

Osteogenesis imperfecta (OI) is an incurable genetic brittle-bone disease. Although drug
therapy, surgery and physiotherapy represent current treatments for OI, the search is …