Learning the chemical grammar of biomolecular condensates

HR Kilgore, RA Young - Nature chemical biology, 2022 - nature.com
Biomolecular condensates compartmentalize and regulate assemblies of biomolecules
engaged in vital physiological processes in cells. Specific proteins and nucleic acids …

Distinct chemical environments in biomolecular condensates

HR Kilgore, PG Mikhael, KJ Overholt, A Boija… - Nature Chemical …, 2024 - nature.com
Diverse mechanisms have been described for selective enrichment of biomolecules in
membrane-bound organelles, but less is known about mechanisms by which molecules are …

[HTML][HTML] CD-CODE: crowdsourcing condensate database and encyclopedia

N Rostam, S Ghosh, CFW Chow, A Hadarovich… - Nature …, 2023 - nature.com
The discovery of biomolecular condensates transformed our understanding of intracellular
compartmentalization of molecules. To integrate interdisciplinary scientific knowledge about …

[HTML][HTML] Modulating biomolecular condensates: a novel approach to drug discovery

DM Mitrea, M Mittasch, BF Gomes, IA Klein… - Nature Reviews Drug …, 2022 - nature.com
In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …

Molecular and environmental determinants of biomolecular condensate formation

JA Villegas, M Heidenreich, ED Levy - Nature chemical biology, 2022 - nature.com
Biomolecular condensate formation has been implicated in a host of biological processes
and has found relevance in biology and disease. Understanding the physical principles and …

A framework for understanding the functions of biomolecular condensates across scales

AS Lyon, WB Peeples, MK Rosen - Nature Reviews Molecular Cell …, 2021 - nature.com
Biomolecular condensates are found throughout eukaryotic cells, including in the nucleus, in
the cytoplasm and on membranes. They are also implicated in a wide range of cellular …

[HTML][HTML] An evolutionarily nascent architecture underlying the formation and emergence of biomolecular condensates

N Jaberi-Lashkari, B Lee, F Aryan, E Calo - Cell reports, 2023 - cell.com
Biomolecular condensates are implicated in core cellular processes such as gene
regulation and ribosome biogenesis. Although the architecture of biomolecular condensates …

[HTML][HTML] Phase separation in biology and disease; current perspectives and open questions

S Boeynaems, S Chong, J Gsponer, L Holt… - Journal of molecular …, 2023 - Elsevier
In the past almost 15 years, we witnessed the birth of a new scientific field focused on the
existence, formation, biological functions, and disease associations of membraneless …

Higher-order organization of biomolecular condensates

CM Fare, A Villani, LE Drake, J Shorter - Open biology, 2021 - royalsocietypublishing.org
A guiding principle of biology is that biochemical reactions must be organized in space and
time. One way this spatio-temporal organization is achieved is through liquid–liquid phase …

Biomolecular condensates in neurodegeneration and cancer

S Spannl, M Tereshchenko, GJ Mastromarco, SJ Ihn… - Traffic, 2019 - Wiley Online Library
The intracellular environment is partitioned into functionally distinct compartments
containing specific sets of molecules and reactions. Biomolecular condensates, also …