Learning the chemical grammar of biomolecular condensates
HR Kilgore, RA Young - Nature chemical biology, 2022 - nature.com
Biomolecular condensates compartmentalize and regulate assemblies of biomolecules
engaged in vital physiological processes in cells. Specific proteins and nucleic acids …
engaged in vital physiological processes in cells. Specific proteins and nucleic acids …
Distinct chemical environments in biomolecular condensates
Diverse mechanisms have been described for selective enrichment of biomolecules in
membrane-bound organelles, but less is known about mechanisms by which molecules are …
membrane-bound organelles, but less is known about mechanisms by which molecules are …
[HTML][HTML] CD-CODE: crowdsourcing condensate database and encyclopedia
The discovery of biomolecular condensates transformed our understanding of intracellular
compartmentalization of molecules. To integrate interdisciplinary scientific knowledge about …
compartmentalization of molecules. To integrate interdisciplinary scientific knowledge about …
[HTML][HTML] Modulating biomolecular condensates: a novel approach to drug discovery
In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …
been reported to play key roles in many cellular functions by compartmentalizing specific …
Molecular and environmental determinants of biomolecular condensate formation
JA Villegas, M Heidenreich, ED Levy - Nature chemical biology, 2022 - nature.com
Biomolecular condensate formation has been implicated in a host of biological processes
and has found relevance in biology and disease. Understanding the physical principles and …
and has found relevance in biology and disease. Understanding the physical principles and …
A framework for understanding the functions of biomolecular condensates across scales
AS Lyon, WB Peeples, MK Rosen - Nature Reviews Molecular Cell …, 2021 - nature.com
Biomolecular condensates are found throughout eukaryotic cells, including in the nucleus, in
the cytoplasm and on membranes. They are also implicated in a wide range of cellular …
the cytoplasm and on membranes. They are also implicated in a wide range of cellular …
[HTML][HTML] An evolutionarily nascent architecture underlying the formation and emergence of biomolecular condensates
Biomolecular condensates are implicated in core cellular processes such as gene
regulation and ribosome biogenesis. Although the architecture of biomolecular condensates …
regulation and ribosome biogenesis. Although the architecture of biomolecular condensates …
[HTML][HTML] Phase separation in biology and disease; current perspectives and open questions
In the past almost 15 years, we witnessed the birth of a new scientific field focused on the
existence, formation, biological functions, and disease associations of membraneless …
existence, formation, biological functions, and disease associations of membraneless …
Higher-order organization of biomolecular condensates
A guiding principle of biology is that biochemical reactions must be organized in space and
time. One way this spatio-temporal organization is achieved is through liquid–liquid phase …
time. One way this spatio-temporal organization is achieved is through liquid–liquid phase …
Biomolecular condensates in neurodegeneration and cancer
S Spannl, M Tereshchenko, GJ Mastromarco, SJ Ihn… - Traffic, 2019 - Wiley Online Library
The intracellular environment is partitioned into functionally distinct compartments
containing specific sets of molecules and reactions. Biomolecular condensates, also …
containing specific sets of molecules and reactions. Biomolecular condensates, also …